READING, MA — The Reading Municipal Light Department (RMLD) will discontinue the use of its smartphone app effective July 31, 2018. The app was initially launched because RMLD’s old website had limited mobile compatibility. The app provided a means for customers to interact with RMLD via their smartphone. This access is now available through RMLD’s new mobile-friendly website, www.rmld.com.RMLD’s new website contains information on RMLD programs and events, energy efficiency tips, allows customers to pay their electric bill, report an outage, and sign up for service, and displays RMLD’s Twitter feed prominently at the top of the page.(NOTE: The above press release is from Reading Municipal Light Department.)Like Wilmington Apple on Facebook. Follow Wilmington Apple on Twitter. Follow Wilmington Apple on Instagram. Subscribe to Wilmington Apple’s daily email newsletter HERE. Got a comment, question, photo, press release, or news tip? Email email@example.com.Share this:TwitterFacebookLike this:Like Loading… RelatedRMLD Cuts Ribbon For New Battery Energy Storage SystemIn “Government”SAVE THE DATE: RMLD To Hold Family-Friendly Open House On October 10In “Community”RMLD Invites Customers To Attend Free Electric Car Show In Wilmington On September 15In “Community”
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WILMINGTON, MA — Below are job listings previously published on Wilmington Apple during the week of April 14, 2019:Full-Time Physical Therapist at Wilmington Public SchoolsFull-Time Customer Service Representative at D.B. RobertsFull-Time Commissioning Manager at Limbach Facility ServicesFull-Time/Part-Tiem Member Services Representative at Planet FitnessFull-Time Warehouse Associate at West Springfield Auto Parts Inc.Full-Time Warehouse Stockroom Associate at NAPA Auto PartsFull-Time Delivery Driver at AFR Furniture RentalFull-Time Crew Chief Technician at SERVPROFull-Time Delivery Driver at FedEx WarehouseFull-Time Senior Mechanical Engineer at AmetekFull-Time Senior Research Scientist at EnergetiqFull-Time Sr. Quality Regulatory Compliance Engineer at EnergetiqFull-Time Office Administrator at EnergetiqFull-Time Director of Engineering at EnergetiqFull-Time Product Support Engineer at EnergetiqPart-Time Temporary Driver at FedExPart-Time Nanny For 1 Wilmington ChildFull-Time CDL Relief Driver at Pepsi Co.Full-Time Landscape Maintenance Crew Leader at Garrick-SantoFull-Time/Part-Time Pizza Counter/Register Help at Wilmington House of PizzaFull-Time Marketing Specialist at Charles River LabsFull-Time Associate Director Marketing at Charles River LabsFull-Time Product Manager (Discovery Oncology) at Charles River LabsFull-Time AV Rack Builder at Red ThreadFull-Time National Accounts Project Coordinator at Standard ElectricPart-Time Inside Sales Associate at Superior SealcoatPart-Time Cashier at K1 SpeedFull-Time Cargo Van Driver at OptimaPart-Time Babysitter For Wilmington TwinsFull-Time Entry Level Sales at Capital Carpet & Flooring SpecialistsFull-Time Driver at West Springfield Auto PartsFull-Time Counter Sales at West Springfield Auto PartsPart-Time Apparel & Accessories Team Member at TargetPart-Time Electronics Team Member at TargetFull-Time Overnight Custodian at Planet FitnessFull-Time Overnight Closer at Planet FitnessFull-Time HVAC Service Technician at InLine Mechanical LLCFull-Time Member Service Representative at Align Credit UnionPart-Time Certified Personal Trainer at NA FitnessPart-Time Sandwich Artist at SubwayFull-Time Class D Delivery Driver at J. Polep Distribution ServicesFull-Time Administrative Assistant/Receptionist at O’Brien ConstructionFull-Time 1st Shift Production Technician at CutisPharmaFull-Time HR Business Partner at Charles River LabsFull-Time Service Manager/Technician at Ritchie & SonsFull-Time Deployment Specialist at Locus RoboticsFull-Time Deployment Project Manager at Locus RoboticsFull-Time Sales Executive at Locus RoboticsFull-Time Inbound Sales Specialist at Parterre Flooring SystemsFull-Time Customer Service/Technician at PALMS Environmental: PALMS Environmental, located in Wilmington, is a rental company serving the Environmental Consultant and Engineering community. We offer a full line of monitoring and sampling equipment for water, soil and air since 1999. We are looking for an individual who can maintain our equipment, interact with customers, perform deliveries and wear many hats as required in a small business. No experience is required, we will train you. This is a full time position and mother’s hours are acceptable. PALMS Environmental offers an excellent working environment, and competitive salary with benefits. Interested candidates should contact: Dennis Hart, firstname.lastname@example.org(NOTE: Wilmington businesses — Feel free to send me your job postings at email@example.com.)Like Wilmington Apple on Facebook. Follow Wilmington Apple on Twitter. Follow Wilmington Apple on Instagram. Subscribe to Wilmington Apple’s daily email newsletter HERE. Got a comment, question, photo, press release, or news tip? Email firstname.lastname@example.org.Share this:TwitterFacebookLike this:Like Loading… RelatedNOW HIRING: 50 New Job Openings In Wilmington (Week of August 18, 2019)In “Business”NOW HIRING: 60 New Job Openings In Wilmington (Week of July 14, 2019)In “Business”NOW HIRING: 60 New Job Openings In Wilmington (Week of August 4, 2019)In “Business”
Raveena Tandon, Salman KhanInstagramSalman Khan and Raveena Tandon go back a long way. She made her debut in Bollywood with Salman in 1991 film Patthar Ke Phool and then went on to star in Andaz Apna Apna which became one of the cult movies of the industry. So it was pretty obvious for Salman to play a prank on Raveena when they reunited on the sets of Nach Baliye 9.The Dabangg Khan told the entire crew of Nach Baliye 9 that he knows Raveena since the last 120 years and spoke non-stop on the set.”He (Salman) told everyone that he knows me since the last 120 years. There’s a comfort factor with him. We spoke non-stop on the set, but when the episode was telecast, I realised that they had edited out a major chunk due to time constraints. We then told each other, ‘Why did we talk so much?'” Raveena Tandon told Mid-Day.Raveena, along with Suniel Shetty, was recently featured in the recreated version of their hit song Sheher Ki Ladki from the 1996 film Rakshak. The video of the remake version also features Diana Penty and Badshah grooving to the song.
Ball-and-stick model of lincomycin. Credit: Jynto/Wikipedia Journal information: Nature Scientists study how marine bacteria release cloud-making compound Citation: Researchers unravel the elusive source of sulfur in an antibiotic (2015, January 15) retrieved 18 August 2019 from https://phys.org/news/2015-01-unravel-elusive-source-sulfur-antibiotic.html Explore further More information: Metabolic coupling of two small-molecule thiols programs the biosynthesis of lincomycin A, Nature (2015) DOI: 10.1038/nature14137AbstractLow-molecular-mass thiols in organisms are well known for their redox-relevant role in protection against various endogenous and exogenous stresses1, 2, 3. In eukaryotes and Gram-negative bacteria, the primary thiol is glutathione (GSH), a cysteinyl-containing tripeptide. In contrast, mycothiol (MSH), a cysteinyl pseudo-disaccharide, is dominant in Gram-positive actinobacteria, including antibiotic-producing actinomycetes and pathogenic mycobacteria. MSH is equivalent to GSH, either as a cofactor or as a substrate, in numerous biochemical processes4, most of which have not been characterized, largely due to the dearth of information concerning MSH-dependent proteins. Actinomycetes are able to produce another thiol, ergothioneine (EGT), a histidine betaine derivative that is widely assimilated by plants and animals for variable physiological activities5. The involvement of EGT in enzymatic reactions, however, lacks any precedent. Here we report that the unprecedented coupling of two bacterial thiols, MSH and EGT, has a constructive role in the biosynthesis of lincomycin A, a sulfur-containing lincosamide (C8 sugar) antibiotic that has been widely used for half a century to treat Gram-positive bacterial infections6, 7, 8, 9. EGT acts as a carrier to template the molecular assembly, and MSH is the sulfur donor for lincomycin maturation after thiol exchange. These thiols function through two unusual S-glycosylations that program lincosamide transfer, activation and modification, providing the first paradigm for EGT-associated biochemical processes and for the poorly understood MSH-dependent biotransformations, a newly described model that is potentially common in the incorporation of sulfur, an element essential for life and ubiquitous in living systems. As Melancon notes, there are a host of molecules vital for biological processes that have sulfur as a component—their metabolic origins can be predicted as a matter of course. Sulfur atoms on the other hand have been much more difficult to predict. Overcoming such obstacles for some molecules could have benefits such as helping to develop new medicines. In this new effort the researchers set their sights on lincomycin A, an antibacterial agent that has been used to treat Gram-positive bacterial infections for many years.To find the sulfur source, the researchers used modern whole genome sequencing techniques to work backwards through likely pathways looking to isolate intermediaries that tended to build up as genes were disrupted. Doing so led to the discovery that disruption of lmbE led to intermediates that looked a lot like lincomycin—that led them to study lambV, a gene that also shows up in lincomycin, which led to the discovery of another intermediary. The team also tested other enzymes and found a way to prove that there were at least three of them that incorporated sulfur into parts of the antibiotic, which was the original goal, of course. More specifically, they found that two bacterial thiols played a constructive role in the biosynthesis of lincomycin A. The team then went further, isolating the materials that were produced due to the genes involved, along with the functions of enzymes that were part of the process.Work done by the team should help provide a pathway for other researchers attempting to find the source of sulfur atoms in other molecules, perhaps leading to new types of materials for use in a variety of medical purposes, from antibiotics to cancer fighting agents. © 2015 Phys.org (Phys.org)—A team of researchers working at the Chinese Academy of Sciences in Shanghai has for the first time found the source of sulfur atoms in lincomycin A, a lincosamide widely used as an antibiotic agent. In their paper published in the journal Nature, the team describes their research efforts and results. Charles Melancon with the University of New Mexico outlines and comments on the work done by the team in the same journal issue. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.