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Woman stole €760K and blew it on high-end fashion

first_imgA 47-year-old woman who stole €760,000 from her employer has pleaded guilty to 20 sample counts of theft at Donegal Circuit Court.Tara Sweeney, with an address at the Glebe in Donegal Town, spent most of the money on high-end fashion goods purchased online. The thefts occurred at the County Donegal Education Centre over a six year period.Sentencing in the case was today has been put back until next March.The court was told that Tara Sweeney was an accounts administrator at the Donegal Education Centre from 2009 until 2015.RTE reports that she had no formal qualifications but was solely responsible for payroll and had full access to seven bank accounts.It was only in June 2015 when a new director was apppointed to the company that suspicions were raised about large amounts of money missing.Tara Sweeney resigned from her job and Gardaí carried out a search of her home. They discovered ten black refuse bags filled with documentation from her workplace.An expenditure analysis by a specialist accounting firm showed electronic credit transfers totalling over €760,000 going into accounts in her name.The court heard the balances in those accounts were moderate given the level of substantial withdrawals.Detective Garda Ciaran O’Brien told the court that the bulk of money was spent on high end fashion goods including designer handbags by Gucci and Prada, cosmetics, sunglasses, clothes, shoes, perfume and jewellery.The court heard that thousands of items were left in bags and boxes unused once they had been purchased.When interviewed by Gardaí, she admitted that she had made all of these purchases but couldn’t remember individual transactions.The court heard she was shocked at the figure of €760,000 thinking it was more in the region of €250,000. This amount she accepted, was also bad.Giving evidence in court, she said she found it difficult to explain her online shopping addiction other than to say she did it to make herself feel better.She had been under a lot stress in the workplace, had lost her mother and was bringing up her son alone.Tara Sweeney apologised to her family and former co-workers for the pain and distress she had caused.A psychiatric report described her as a loner who had suffered depression in the past but she showed no signs of mental illness and had accepted full responsibility for her actions.Peter Nolan, barrister for Tara Sweeney, said she had indulged in behaviour that was the ruination of her life.He said she had been chasing an illusion whereby purchasing thousands of luxury goods would sort out her life.He said Ms Sweeney was now unemployed and facing repossession of her house.He asked Judge John Aylmer not to send her to prison saying she had engaged in criminal activity but was not a “typical criminal”. Tara Sweeney had no previous convictions.The Judge deferred sentencing until next March.The County Donegal Education Centre have issued proceedings in an effort to recover some of the monies lost.Woman stole €760K and blew it on high-end fashion was last modified: December 19th, 2019 by StephenShare this:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on Reddit (Opens in new window)Click to share on Pocket (Opens in new window)Click to share on Telegram (Opens in new window)Click to share on WhatsApp (Opens in new window)Click to share on Skype (Opens in new window)Click to print (Opens in new window) Tags:courtdonegalFashionTara Sweeneytheftlast_img read more

Mandela Day a ‘catalyst for unity’

first_img16 July 2013 Nelson Mandela Day should serve as a catalyst for fostering social cohesion, nation building, economic development and inclusive citizenship, the Department of Arts and Culture said on Monday. Marked across the world on 18 July each year, Mandela Day aims to inspire people to take action to change the world for the better and, in doing so, to build a global movement for good. People around the world are challenged to spend at least 67 minutes doing good work in their communities in honour of the 67 years that Mandela gave in service and sacrifice. South Africa’s focus this year would be “on community development and a call to everyone to use their energies, wisdom and skills to contribute towards eradicating poverty, addressing food security and reducing hunger”, the department said in a statement. Arts and Culture Minister Paul Mashatile and his deputy, Joe Phaahla, will get a first-hand look at progress made at the Nelson Mandela Museum in Mthatha in the Eastern Cape on Wednesday. The museum has been temporarily closed for refurbishments to improve preservation standards and create more exhibition space. On Mandela Day, Mashatile and Phaahla will visit Qunu Junior Secondary near Mthatha, where Mandela attended as a boy, to donate books to the school’s arts centre. The department will also help to clean and beautify the school through public art, and install flags in 10 surrounding schools. SAinfo reporterlast_img read more

Climate-Specific Air Conditioners

first_imgIf you live in a humid climate (for example, in Florida), you need an air conditioner that does a good job of dehumidification. But if you live in a dry climate (for example, in Nevada), dehumidification is almost irrelevant, because the outdoor air is so dry. In Nevada, all you need is an air conditioner that lowers the temperature of the air in an energy-efficient way.In theory, air conditioner manufacturers could tweak the design of their equipment to focus mainly on lowering the indoor air temperature (a process known as sensible heat removal), or they could produce equipment that devotes a lot of energy to dehumidification (a process known as latent heat removal). Unfortunately, though, air conditioner manufacturers don’t offer special equipment designed for dry climates. Instead, they sell the same equipment in Nevada that they do in Florida.Most residential air conditioners sold in the U.S. are designed to operate at a sensible heat ratio between 0.75 or 0.80. (The sum of the sensible load and the latent load is the total load; the sensible heat ratio is the sensible load divided by the total load.) If you live in a very humid climate, this sensible heat ratio might be too high. If you live in a very dry climate, this sensible heat ratio is definitely too low.John Proctor is the president of Proctor Engineering Group in San Rafael, California, and a nationally known expert on residential cooling. Proctor has always been irked by the failure of air conditioner manufacturers to address regional needs. “Air conditioners are designed and installed the same for Florida and Arizona,” says Proctor. “It makes no sense, since Florida and the Southwest have different climates and different cooling needs.”To improve the efficiency of air conditioners in dry Southwestern states, Proctor has… This article is only available to GBA Prime Members Sign up for a free trial and get instant access to this article as well as GBA’s complete library of premium articles and construction details.center_img Start Free Trial Already a member? Log inlast_img read more

Filmmaking Tips: How To Record Live Music in Your Films

first_imgThe filmmakers behind La Barracuda share their secrets to filming and recording live music in their OCFF-winning narrative feature.All images via La Barracuda.There’s an undeniable power to films that find creative ways to feature music as an integral part of a film’s narrative. One recent example is La Barracuda, a “slow-burn Texas thriller brimming with tension and a lot of music,” which screened at the Oak Cliff Film Festival, fresh off of its lauded premiere at SXSW a few months earlier.Filmmakers Jason Cortlund and Julia Halperin (who are pictured below receiving the narrative feature award and prize package at the OCFF) had to find creative ways to make a musical world come to life within a film that is deeply rooted in the rich country and folk music scene in Austin, Texas.It was important to us that the performances and music culture be woven into the story in natural and subtle ways because we trust our audience to know better — and music’s really the key to understanding the story.’ Within a limited indie budget, we were tasked with finding a way to record ‘live’ music to create scenes and atmosphere that looked, felt, and most importantly, sounded true to form.If you’re looking to tug your audience’s heart strings by using “live” music on a project of your own, you may want to check out these filmmakers’ tips before recording.You Don’t Have to Fake It to Make ItWhen we started casting, we were committed to finding someone who could act, sing, and play guitar for the lead role of Sinaloa. But there were lots of people along the way pushing us to consider casting a bigger name actress and just faking the guitar playing scenes with inserts of a hand double. While that would have potentially made the film much easier to finance, it would strip out the heart of what we were going after.One of the most endearing aspects of a film like La Barracuda is the authenticity of its characters and their relationships with the music in the film. Lead actress Sophie Reed‘s character (Sinaloa) actually performed her songs herself — which can both be helpful and problematic.Know Your RightsWe knew that negotiating song licenses can be tricky and expensive, so we brought in a music supervisor during development. History is littered with films that can’t be distributed because of music rights issues. We had to be careful and not get our hearts set on any song in particular until we knew we could afford the license. We also learned that the public domain can be tricky — while traditional lyrics might be free to use, a specific musical arrangement may require its own license.Using music in films, even original compositions, can get tricky very quickly in terms of licensing. It’s important, as in the case of La Barracuda, to do your research and work with a music supervisor from the very beginning — lest you film scenes with live music that you can’t actually use in your final cut.Camera and Sound Departments Need to Work TogetherThe camera can be a bully. Because the frame gets so much attention in terms of lighting and mise en scene, the sound department can become a whipping boy — forced to always make compromises that must then be reconciled in post. Not only does this just forestall dealing with a problem, it also makes for a bummer crew dynamic. As directors, we consciously try to treat sound and camera (and all departments) with equal respect.As any sound mixer will tell you, this certainly rings true on all sets. Cinematography seems to always be the head honcho; however, for a film whose soul is the music, it takes a special relationship between sound and camera departments — expertly demonstrated by La Barracuda‘s director of photography (Jonathan Nastasi) and sound mixer (Paul Toohey). Their collaboration found a way to balance the two elements masterfully.Use the Board In addition to multi-track field recordings of live music performances (often with lavs inside every instrument, and on every singer, and a double boom), when we were in venues like The Saxon Pub or The Old Coupland Dancehall, we made use of their in-house mixing boards as well. We had brought in live-event sound mixers to capture secondary recordings from the board feed via the house mics — which gave us many more options in post (as well as clean recordings for a potential soundtrack release).This is actually a pretty clever workaround as a way to record “live” music authentically while making opportunistic use of the environment. While not every scene will be in a bar or concert venue, that doesn’t mean board mixing is out of the question. Having a board on set can often be a great tool for balancing everything from music to recording dialogue.Have Faith — Music Will Add LayersWhile the musical elements definitely added layers of cost and complexity to the production, they’re also the soul of the film. We shot our first live song on day three, and we could see the lights go on with all our crew — someone literally said “Oh! THIS is the film we’re making.” It instantly made everyone so happy, and it drew us together for the rest of the show. Overhearing our key grip (a burly, tattooed dude who goes by “Animal”) humming a sweet Mastersons tune as he loaded the truck that night gave us all the reassurance we needed — the effort would pay dividends in screen pleasure.At the end of the day, the choice to use music in the film depends on how much it can add to the story and overall production. Not every project needs “live” music scenes (as they can be quite tricky). However, in the case of La Barracuda, it proves that going the extra mile to record authentic music performances can create something unique that audiences (and the crew) can feel.Samuel Goldwyn Films picked up La Barracuda, it will see a theatrical release in the U.S. this fall. Check out the Facebook and Twitter pages for updates on upcoming screening dates and locations.last_img read more

Golovkin and Alvarez to meet in May 5 rematch

first_imgOnyok Velasco see bright future for PH boxing in Olympics PLAY LIST 00:45Onyok Velasco see bright future for PH boxing in Olympics05:25PH boxing team determined to deliver gold medals for PH01:49Pacquiao to Mayweather: Want fans to stop asking for rematch? Then fight me again01:29Police teams find crossbows, bows in HK university01:35Panelo suggests discounted SEA Games tickets for students02:49Robredo: True leaders perform well despite having ‘uninspiring’ boss02:42PH underwater hockey team aims to make waves in SEA Games01:44Philippines marks anniversary of massacre with calls for justice01:19Fire erupts in Barangay Tatalon in Quezon City Kammuri turning to super typhoon less likely but possible — Pagasa View comments LATEST STORIES Slow and steady hope for near-extinct Bangladesh tortoises Read Next 2 ‘newbie’ drug pushers fall in Lucena sting Globe Business launches leading cloud-enabled and hardware-agnostic conferencing platform in PH Typhoon Kammuri accelerates, gains strength en route to PH MOST READ John Lloyd Cruz a dashing guest at Vhong Navarro’s wedding Brace for potentially devastating typhoon approaching PH – NDRRMC Boxer Canelo Alvarez (L) and WBC, WBA and IBF middleweight champion Gennady Golovkin pose during their official weigh-in at MGM Grand Garden Arena on September 15, 2017 in Las Vegas, Nevada. Golovkin will defend his titles against Alvarez at T-Mobile Arena on September 16 in Las Vegas. AFP/GETTY IMAGESGennady Golovkin and Canelo Alvarez will meet in a May 5 rematch with the middleweight title on the line once again, promoters said Monday.Still to be announced is the location, though Las Vegas is considered the front runner for the fight on Cinco de Mayo weekend.ADVERTISEMENT NEXT BLOCK ASIA 2.0 introduces GURUS AWARDS to recognize and reward industry influencers Rousey’s WWE deal gets ex-UFC star back in bright spotlight Don’t miss out on the latest news and information. Golovkin and Alvarez fought to a controversial 12-round draw in September, after which both fighters said they wanted a rematch. It took promoters months to negotiate the terms for what is expected to be one of the biggest pay-per-view fights of the year.The two fighters have only one loss between them, with Golovkin 37-0-1 with 33 knockouts and Alvarez 49-1-2 with 34 knockouts.FEATURED STORIESSPORTSWATCH: Drones light up sky in final leg of SEA Games torch runSPORTSLillard, Anthony lead Blazers over ThunderSPORTSMalditas save PH from shutoutlast_img read more

Aparna Sen receives national film award for best direction for 36 Chowringhee Lane

first_imgDeepti Divaker: Multi-dimensionalAll Bombay models have stars in their eyes – film stars, that is. But few get there and fewer still have the kind of vital statistics that Deepti Divaker, 22, flaunts. For starters, a 35-24-35 figure that, coupled with unusual poise and confidence, earned her the Miss India,Deepti Divaker: Multi-dimensionalAll Bombay models have stars in their eyes – film stars, that is. But few get there and fewer still have the kind of vital statistics that Deepti Divaker, 22, flaunts. For starters, a 35-24-35 figure that, coupled with unusual poise and confidence, earned her the Miss India title in last year’s Femina contest. That isn’t all. Under that elegantly-upholstered exterior is a rare hybrid: painter, writer, classical dancer, architect and fashion model, all struggling to get out at the same time. Just back from Britain and an unsuccessful bid for the Miss World title, Divaker is currently back at her drawing board in Bangalore where she is studying architecture. But not for long. Her first priority is to recover the money she spent for her London trip. “I spent Rs 12,000 on that trip from my own pocket. Femina only paid for my return ticket,” she drawls, “I’m determined to recover the money from dancing, modelling, and acting.” Next stop: Bombay, where she intends to take the film industry by hurricane. And then: the world. “I want to be multidimensional,” she insists, “I want to try my hand at everything. What I want while I’m still young is fame, lots of it, and money too.” That figures.(from left)Aparna Sen; Om Puri in Arohan and Rekha in Umrao Jaan: Winning performancesWith two big guns of the Bombay film industry on the jury that decided the 29th national film awards last fortnight, there were rumours that the commercial entertainer might achieve respectability by winning a laurel. However, grand old actor Ashok Kumar, chairman of the feature film jury – his other Bombay colleague was producer-director B.R. Chopra – had other, and better ideas and the Swaran Kamal for the best feature went to Dakhal, the creation of young Bengali director Gautam Ghose. The other awards are less of a surprise. Aparna Sen received the prize for best direction for the film 36 Chowringhee Lane. Om Puri, the exploited peasant of Shyam Bengal’s Arohan, was best actor – he plays a similar exploited peasant in Satyajit Ray’s Sadgali, which got a special jury award, best actress was Rekha, the poetic courtesan of Umrao Jaan. In fact, Muzaffar All’s period piece, set in ceremonious Lucknow, walked away with four awards – best actress, best playback singer (Asha Bhonsle), best music director (Khayyam) and best art direction.R. Gundu Rao: Donkey dropsHeat does strange things to people. With the mercury rising above 36 degrees in Bangalore, Karnataka Chief Minister R. Gundu Rao took cricket bat in hand and led a motley team of legislators, ministers and close friends – including bosom buddy F.M. Khan – out on to the field to confront the High Court chief justice’s eleven. Decked out in sharply creased flannels. his belly squeezed behind a striking sports/shirt, Rao turned his arm over for a few donkey drops before wilting away and letting his team-mates take over. At the other end, Chief Justice D. Chandrashekhar made two runs before he, too, strolled back to the cool of the pavilion. State Finance Minister Veerappa Moily and Khan did their duty valiantly after their master left, but even so the chief justice’s men managed to score 144 runs. In reply, after much huffing and puffing, Rao’s team could score only 129 – which is probably his government’s best performance.advertisementlast_img read more

a month agoWatford boss Quique Sanchez Flores: We’re looking for some kind of style

first_imgWatford boss Quique Sanchez Flores: We’re looking for some kind of styleby Paul Vegasa month agoSend to a friendShare the loveWatford boss Quique Sanchez Flores admits their performance was not good enough in their 2-0 defeat at Wolves.Matt Doherty’s opener was added to by Daryl Janmaat’s own goal after the break, which saw Wolves pick up three points and rise up the table. The Hornets head coach said: “We knew today would be a different match [to the defeat at Manchester City] and it would be tough. It’s not enough, it’s clear the performance should be better.“Now we are looking for some kind of style, some way we’re going to play, but at the moment we’re not playing in that way. We concede very easy goals and these destroy all the plans. We are playing [catch-up] behind the score so it’s difficult for the players right now.”Asked what it would take to turn the corner, Sanchez Flores responded: “Winning. We need to win. We need to train hard, we need to improve, we’re stronger on the training ground every single day but in the matches we still have problems, we have insecurities, we have situations we can’t solve, easy mistakes giving opportunities to the opponent.” About the authorPaul VegasShare the loveHave your saylast_img read more

Captivating Let the Dance Begin performance set

first_img Captivating ‘Let the Dance Begin’ performance set for the AlleyDerry and Strabane CouncilstrabaneTHE ALLEY THEATRE THE finale of a six-week community arts and wellbeing project ‘Let the Dance Begin’ will take place in the Alley Theatre, Strabane on Thursday, February 7, 2019.It promises to be a captivating performance which will see community groups and schools collide ‘On the Air’ for a celebration of dance, music, art and the spoken word.Supported by Derry City and Strabane District Council and in partnership with Arts Care, The Pushkin Trust and the Public Health Agency, ‘Let the Dance Begin’ is an inclusive arts, education and wellbeing project now in its sixth year. The project has seen Strabane buzzing with the participation of schools, community groups and businesses alike in a celebration of local creativity.The showcase of performance work created during the project is not to be missed and promises to be a vibrant, inclusive display of dance, drumming, poetry and much more!A pop-up gallery can also be found in the Alley Theatre on 31st January and 1st February hosting visual art and creative writing created during the project by local community groups and schools.Tickets for the ‘Let the Dance Begin’ performance at 7pm on Thursday 7th February are £3 available from the Alley Theatre Box Office on 02871 384444 or www.alley-theatre.com Captivating ‘Let the Dance Begin’ performance set for the Alley was last modified: January 21st, 2019 by John2John2 Tags: ShareTweetlast_img read more

Lithuanian researchers develop smart wristworn device for monitoring atrial fibrillation

first_imgReviewed by Alina Shrourou, B.Sc. (Editor)Mar 26 2019Although smart wristbands are popular fashion gadgets for monitoring heart rate and physical activity, they are usually not sophisticated enough to provide specific and accurate information about potential health problems of the wearer. Kaunas University of Technology (KTU), Lithuania researchers are developing a smart wrist-worn device for monitoring of atrial fibrillation – a condition, which if left untreated can lead to serious health complications and even death.According to the data provided by the US government, atrial fibrillation is the most common type of heart arrhythmia. Approximately 9% of people aged 65 years or older have atrial fibrillation; it is estimated that due to the rapidly aging society, the prevalence of the disease in the global population will increase 3-fold in the next 30 years.At the beginning of arrhythmia development, the episodes are usually short and self-terminating thus may remain unnoticed. If untreated, atrial fibrillation can contribute to the development of serious complications, such as brain stroke.”Atrial fibrillation can often develop after a heart attack, thus these patients need certain medical care and attention to prevent from serious health complications. However, after leaving the hospital their health check-ups are only episodic. Non-invasive, compact wearable devices, which are providing continuous monitoring is an attractive solution for monitoring the health status of such high-risk groups”, says Vaidotas Marozas, the Director of KTU Biomedical Engineering Institute (BEI).The team of KTU BEI researchers, led by Dr Marozas is developing a multisensory system, i.e. the wrist-worn device for atrial fibrillation monitoring. Two types of modalities are being used in the device – photoplethysmographic (PPG) for continuous monitoring and electrocardiographic (ECG) for the acquisition of a control signal. When the PPG sensor registers the heart activity akin to atrial fibrillation, the device vibrates mildly, asking the patient to touch the device with the other hand in order to register a short ECG signal.The quality of vital signals acquired in real life is worse than those recorded under clinical conditions. Therefore, continuous monitoring – or the remote observation of patients- is only made possible through high-quality data. According to Dr Marozas, one of the main challenges in the development of the wearable monitoring systems is advanced signal processing solutions which would separate useful information from the “noise” i.e. motion artifacts and other types of arrhythmia. The biomedical engineers of KTU are working together with the international team of physicians and health scientists from Kaunas University of Health Sciences, Vilnius University, Lund University, and industrial designers from Vilnius Academy of Arts.Related StoriesStudy explores role of iron in over 900 diseasesHeart disease is still the number 1 killer in Australia, according to latest figuresResearchers discover gene linked to healthy aging in worms”We are focusing on developing technologies, which are needed for the public and contemporary medicine. For example, due to the prevalence of this condition, every person older than 65 should be checked for atrial fibrillation. However, relying on the short-term clinical ECG, the arrhythmia can be detected only if the condition is chronic. What if the episodes are occurring only occasionally? Then our technology is very useful”, explains Dr Marozas.He assures that despite complicated technology and sophisticated algorithms the smart wrist-worn device is very easy to use. It is aimed at seniors – people, who are especially self-conscious when using technologies and smart devices.At the moment, the team is working on adding additional functions to the technology, such as implementing the algorithm of monitoring the heart’s response to physical load. Slow heart’s adaptation to physical load is related to increased mortality rate and risk of cardiovascular disease, therefore monitoring of this parameter could be valuable for people of all ages.The patent application for the smart wrist-worn device has been submitted to the Lithuanian State Patent Bureau at the end of 2018. The KTU BEI team is preparing international applications for two other inventions.KTU Biomedical Engineering Institute is specializing in developing non-standard electronic systems for monitoring human health parameters; usually for research purposes. Together with local and international partners, the KTU researchers have implemented many innovative solutions under the concept of “wearable health”, such as a smart T-shirt, multisensory system for hemodialysis, monitoring system for divers, used in military training.Source: https://en.ktu.edu/news/smart-wrist-worn-device-developed-by-lithuanian-researchers-can-alert-about-dangerous-health-conditions/last_img read more

Researchers discover unique approach to treat some chronic inflammatory diseases

first_imgReviewed by James Ives, M.Psych. (Editor)Apr 12 2019Inflammation is a balanced physiological response — the body needs it to eliminate invasive organisms and foreign irritants, but excessive inflammation can harm healthy cells, contributing to aging and chronic diseases. To help keep tabs on inflammation, immune cells employ a molecular machine called the NLRP3 inflammasome. NLRP3 is inactive in a healthy cell, but is switched “on” when the cell’s mitochondria (energy-generating organelles) are damaged by stress or exposure to bacterial toxins.However, when the NLRP3 inflammasome gets stuck in the “on” position, it can contribute to a number of chronic inflammatory conditions, including gout, osteoarthritis, fatty liver disease and Alzheimer’s and Parkinson’s diseases. In a new mouse study, researchers at University of California San Diego School of Medicine discovered a unique approach that might help treat some chronic inflammatory diseases: force cells to eliminate damaged mitochondria before they activate the NLRP3 inflammasome.The study, published April 11, 2019 by Cell Metabolism, was led by senior author Michael Karin, PhD, Distinguished Professor of Pharmacology and Pathology and Ben and Wanda Hildyard Chair for Mitochondrial and Metabolic Diseases at UC San Diego School of Medicine, and first author Elsa Sanchez-Lopez, PhD, a senior postdoctoral researcher in Karin’s lab.In a 2018 study published in Nature, Karin’s team had shown that damaged mitochondria activate the NLRP3 inflammasome. The researchers also found that the NLRP3 inflammasome is de-activated when mitochondria are removed by the cell’s internal waste recycling process, called mitophagy.”After that, we wondered if we could reduce harmful excess inflammation by intentionally inducing mitophagy, which would eliminate damaged mitochondria and should in turn pre-emptively inhibit NLRP3 inflammasome activation,” Karin said. “But at the time we didn’t have a good way to induce mitophagy.”Related StoriesUK charity invests £1 million to develop potential therapeutic for Parkinson’sStudy sheds light on complex caspase-1-induced cell death mechanismsUTA professor awarded $2.88 million for novel research on Lou Gehrig’s diseaseMore recently, Sanchez-Lopez was studying how macrophages regulate their uptake of choline, a nutrient critical for metabolism, when she discovered something that can initiate mitophagy: an inhibitor of the enzyme choline kinase (ChoK). With ChoK inhibited, choline is no longer incorporated into mitochondrial membranes. As a result, the cells perceive the mitochondria as damaged, and cleared them away by mitophagy.”Most importantly, by getting rid of damaged mitochondria with ChoK inhibitors, we were finally able to inhibit NLRP3 inflammasome activation,” Karin said.To test their new ability to control NLRP3 inflammasome in a living system, the researchers turned to mice. They discovered that treatment with ChoK inhibitors prevented acute inflammation caused by uric acid (accumulation of which triggers gout flares) and a bacterial toxin.By several measures, ChoK inhibitor treatment also reversed chronic inflammation associated with a genetic disease called Muckle-Well Syndrome, which is caused by mutations in NLRP3 genes. One such measure is spleen size — the larger the spleen, the more inflammation. The spleens of Muckle-Well Syndrome mice are on average twice as large as normal mice, but their spleen sizes normalized after ChoK inhibitor treatment.NLRP3 inflammasome promotes inflammation because it triggers the release of two very potent pro-inflammatory molecules called cytokines: interleukin (IL)-1? and IL-18. According to Karin, there are existing drugs that can block IL-1?, but not IL-18. ChoK inhibitors, his team found, can reduce both cytokines.”There are several diseases, including lupus and osteoarthritis, whose treatment will likely require dual inhibition of both IL-1? and IL-18,” Karin said. Source:https://ucsdnews.ucsd.edu/pressrelease/in_mice_eliminating_damaged_mitochondria_alleviates_chronic_inflammatory_diseaselast_img read more