Would an embryonic stem cell by another name cease being human? Several recent articles on embryonic stem cells are going beyond just touting the potential cures from the controversial research, which involves creating and destroying a human embryo. Some are blurring the line between embryonic and adult stem cells (cf. 12/02/2006) and attempting to avoid ethically-charged language. Here are some ways that reporters are trying to make ES cells more palatable to the public:ES joins the army: An article on Science Daily claims that embryonic stem cells are being recruited in the war on terror. A University of Georgia research claims that neural cells induced to multiply from stem cells can detect toxins in the environment, like on a battlefield. The article fails to mention, however, why embryonic stem cells are needed, and whether adult stem cells could do the job just as well (cf. 07/19/2007). It also begins with this misleading clause that suggests that embryonic stem cells have already produced cures: “For more than a decade, Steve Stice has dedicated his research using embryonic stem cells to improving the lives of people with degenerative diseases and debilitating injuries.” The record shows, however, that only adult stem cells have produced therapies that can improve the lives of people, while embryonic stem cells arouse fears of a new era of eugenics (12/16/2006, 11/29/2006 08/13/2006).Get over it: The Editorial in Nature 9/27 urged Germans to get over their ethical qualms about embryonic stem cells and get with the international stem cell gold rush (cf. 12/16/2005). Some German ethicists have pointed to the success of adult stem cells to show that embryonic stem cells are unnecessary. In urging a change, Nature used only bandwagon arguments (cf. 07/31/2006): “The majority of scientists agree that work on both adult and embryonic sources of stem cells should run in parallel until much more is understood about their biology,” the editorial said. “But Germany is out of step with most European countries in permitting research only on human embryonic stem-cell lines that were created before January 2002, when regulations were first laid down.” The article admitted that the creation of new ES cell lines “involves destroying human embryos,” but urged scientists to step up their campaigns against the opponents of the controversial research – many of whom are still smarting from the bad reputation Germany inherited from human medical research atrocities of the Nazis (04/07/2005, 02/28/2006, 12/16/2006).Kahuna: In the same issue, Nature published an interview with Alan Trounson, newly appointed head of California Institute for Regenerative Medicine (CIRM) – the $3 billion stem-cell center approved by California voters. The differences in success between adult and embryonic cells were blurred in his statement, “Mesenchymal [multipotent] stem cells are already in clinical trials. Embryonic stem cells (ESCs) are coming of age….” His ending statement was even more telling: “Adult stem cells are happening. Embryonic stem cells will come into use, and they won’t be immediate cures for everything. You need drugs and protocols as well as the cells, and you’ve got to work with the immune system.” Yet California voters had been swayed by tear-jerking stories of invalids who would be cured by embryonic stem cells. The problems from subjects’ immune systems rejecting embryonic stem cells have so far rendered them medically useless. On top of that, Trounson made it clear that no cures are forthcoming any time soon (cf. 10/13/2006).Loaded words: Because the words “embryonic” and “cloning” are touchy with the public, the US Human Embryonic Stem Cell Registry is changing its name to the Human Pluripotent Stem Cell Registry. Monya Baker reported in Nature 9/27 that this was intended to downplay ethically-charged words. Baker quoted a professor of rhetoric who called this “linguistic deflation of public anxiety.” The center was reacting to an executive order from President Bush that stem cell lines be expanded “in ethically responsible ways.” The same issue of Nature pointed to a promising avenue of research that might solve the ethical problems. “For practical and ethical reasons, researchers are on the lookout for ways to reprogramme one mature cell type into another,” said Huafeng Xie and Stuart H. Orkin in News and Views. “In one case, this might be as easy as switching off a single gene.” They highlighted research that showed it may be possible to turn one kind of cell into another kind through a process of “cellular reprogramming.” They pointed to a paper in the same issue by Cobaleda et al who found that “mature B cells can be converted to functional T cells, and reprogramming is achieved by B cells taking a step backwards to assume a more immature state.” If so, it might become possible to take adult cells from a person and convert them back into an embryonic state – no ethical qualms involved. “Such insights will, in turn, make the alteration of cell fates using modulation of gene expression and the generation of a specific cell population possible, which is a primary goal of regenerative medicine.” See also the 06/06/2007 and 08/25/2006 entries.As we have shown repeatedly before, ES stem-cell advocates are pushing their agenda past the ethical gatekeepers on selfish, pragmatic grounds, yet have no results to show for it. The appeals are always for Nobel Prizes and staying ahead in the international sweepstakes. Whenever an ethicist calls them on the questionable reasoning of taking one life to help another (07/11/2005), they hum and guffaw and dodge the issue. Now they are trying to blur the language with euphemisms to pull the wool over our eyes. Don’t let them get away with it (07/19/2007).(Visited 13 times, 1 visits today)FacebookTwitterPinterestSave分享0
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APTN National NewsA positive learning environment and a sense of belonging are important to all students.But if you’re First Nation, Inuit or Metis in an urban environment it could be tough to feel connected in place without culture.That’s why the Ottawa District School Board and Aboriginal community are making changes in local schools.APTN’s Annette Francis has that story.
Ashley BrandsonAPTN NewsA group of environmentalists from the Hollow Water First Nation who call themselves “What the Frack” are demanding answers as to how a silica sand project, run by Canadian Premier Sand, was approved.The group was at the Manitoba legislature chasing down the minister of Sustainable Development.They want to know if a work permit was granted to Canadian Premier Sand to begin construction.“We’ve never received a straight answer,” said Don Sullivan. “it’s either yes, or no we haven’t.”Canadian Premium Sand is spearheading a project called Winipigow Sand.The company is in discussions with chief and council about plans to build an industrial plant to extract silica sand from Hollow Water and nearby communities of Seymourville, and Manigotagan.“I live there, this is my home,” said Hollow Water members Reg Simard. “I don’t want my home be… to be bulldozed.”Simard said the proposed mine is five to six kilometres from his house and he has concerns about the company’s proposal.“They come in and tell us all the great things about this,” he said. “All the positives, now granted there is a lot of positives uh – to the project but at what cost?”His main concern is about the air quality around the area once the project is approved.APTN News requested an interview with the Rochelle Squires, the minister of Sustainable Development.Her office said she was not available but in an email statement, the minister said that, “The company has submitted an Environmental act proposal which the province is currently reviewing. Crown-Indigenous consultation has begun.“Environmental safety, including health and safety, is a component of the company’s Environment Act proposal, which is currently under review.”firstname.lastname@example.org@ashleybrandson
The world was taken by surprise when an utterly defenceless and unsuspecting lot of people gathered to offer prayers at New Zealand’s Christchurch mosques and were gunned down simply for the names they bore. The immediate reason for this terror attack is the gun laws that make it easy for civilians to possess firearms. This grave public concern seems to have been addressed rather promptly with the Prime Minister’s announcement to alter gun laws in the country and that there isn’t a better time to do it than now – remarkably a very distinct stand to take compared to the world’s bulldozing superpower, the USA. Prime Minister Jacinda Ardern advocated a wider public health approach that seeks to reduce deaths from gun violence; instead of focusing on the unrealistic change in human behavior of possible murders, she assertively talks about creating an environment where people are less likely to fall victim to gun violence. Without the rhetorics of labeling perpetrators of gun violence as good or bad or unwell, she acknowledged the seriousness of the hazard of civilians possessing weapons and that it is an inherently dangerous thing and that guns must be made much harder to get. As much as the menace of gun violence keeps the discussions going, the underlying but still much too obvious matter of white supremacy is brought to highlight by none other than Prime Minister Jacinda Ardern herself. The popular rant of ‘terrorism does not have a religion’ was empty noise until now. Ms. Ardern’s compassion and leadership have directed attentions to the underside of terrorism: just intense intolerance for the ‘other’, without any labels of religion or ethnicity. Her empathy and solidarity with the targeted community have a set a formidable example of good leadership on the global platform. Her sensitivity to the bereaved and firmness against the perpetrator of the attacks who deserves no sympathy or attention, is for world leaders to appreciate and emulate.
Ghaizbad/GB Nagar: With just a couple of days left for Ghaziabad and Gautam Buddh Nagar districts to go polling, the star campaigners and big names of various political parties are leaving no stone unturned and are conducting massive rallies to attract voters in their own ways.A massive gathering of crowd was witnessed at Ramleela Maidaan in Kavi Nagar area of Ghaziabad, where thousands of people thronged the rally organised by Samajwadi Party Chief Akhilesh Yadav campaigning for their candidate, Suresh Bansal, for Ghaziabad Lok Sabha seat. Addressing public on the occasion, Yadav lashed out at BJP government on employment, farmer’s issues and spreading falsehood among people. “The leaders of Bhartiya Janata Party (BJP) are only busy in spreading false achievements while none of the promises of their manifesto turned a reality. All the major infrastructure projects in Ghaziabad district, including the single pillar elevated road, metro line extension from Dilshad Garden to New Bus stand in Ghaziabad, were completed in the rein of Samajwadi Party. However, the present Chief Minister of Uttar Pradesh, Yogi Adityanath is just cutting ribbons and taking credit. There are no new development works started by the BJP government in past couple of years while those which were incomplete in our rein are still incomplete,” said Yadav. Yadav added that the leaders of BJP party may talk about Smart City Ghaizbad but don’t know the condition of slum and backward areas in Ghaziabad where people are still facing a havoc in their day to day life. Another rally was conducted by BSP supremo Mayawati in Knowledge park area of Greater Noida on Monday afternoon. Over 25,000 people gathered in the ground to hear the campaign speech. Addressing a packed ground, Mayawati slammed the BJP’s “Chowkidar” campaign, calling it a gimmick from a government. “The BJP government used to come up with something new as they came up as chaiwala and asked youths to to start the business of frying pakoras and now they have come as chowkidar. Instead of creating job opportunities, which they had promised in previous elections, they are motivating youths to become chowkidars or fry pakoras,” said Mayawati. She further lambasted the government for their decision such as Demonetisation and GST which she claimed to have broken the back bone of businessman and middle class people. In yet another effort to attract voters, BJP candidate Gen (retd) VK Singh also conducted a road show in Ghaziabad’s old City area along with Uttrakhand Chief Minister Trivender Singh Rawat. The political rally of Congress leader Sachin Pilot’s in Ghaziabad was cancelled due to unavoidable circumstances at the last moment on Monday and is expected to take place on Tuesday.
The Milwaukee Brewers took advantage of an ice-cold hot-stove season last winter to become the rare team to win in the offseason and in the regular season. By agreeing Wednesday night with free-agent catcher Yasmani Grandal on a one-year, $18.25 million deal, the Brewers again took advantage of an opportunity to find tremendous value. As most teams zig in another slow offseason, the Brewers, again, zag.While Grandal didn’t have a great postseason with the Dodgers last fall, he was one of the best players available on the free-agent market. According to the Baseball Prospectus version of wins above replacement, which includes a catcher’s pitch-framing ability, Grandal was the 14th most valuable position player in baseball last season (5.0 WAR) and the eighth most valuable player per plate appearance (5.8 WAR per 600 plate appearances) among qualified hitters.That was not a fluke.In terms of total value, Grandal was the No. 1 position player by WAR per plate appearance in 2016 (8.7 WAR per 600 plate appearances), and he ranked seventh in 2017. Over the past four seasons, he was worth 21.2 total WAR. That’s star-level production. He turned 30 in November, so he’s not ancient in baseball terms. But despite all this going for him, Grandal settled for a one-year deal.The switch-hitter offers rare power and patience at the catcher position. Over the past four seasons, his walk rate of 12.8 percent ranks 19th among all MLB batters. His .453 slugging mark ranks third among all qualified catchers, and his 116 weighted runs created plus, a measure of offensive ability that adjusts for park and run-scoring environments,1100 is league average. trails only Gary Sanchez and Buster Posey.Not only is Grandal’s offense rare at his position, but his ability to frame pitches — to get more borderline pitches called favorably — gives him tremendous value at the plate and behind it.Grandal led all catchers in framing runs last season (15.7 runs saved above average). He ranked fourth in 2017 and second in 2016. Even as catchers as a group have improved their ability to receive or frame pitches, raising the floor of the skill, Grandal has maintained his edge. By runs saved, framing is more valuable than blocking balls in the dirt, an area in which Grandal is not as adept.Consider the following visual evidence of Grandal’s magic behind the plate last season. As a Clayton Kershaw slider darted slightly outside the strike zone, Grandal’s glove moved it back to within the confines of the zone. A pitch that should have been called a ball then appeared to be a strike.Grandal managed to softly absorb this high-and-away Kershaw fastball and make it appear to finish as a strike. It’s a subtle but valuable skill.Grandal was attached to a qualifying offer, meaning that the team signing him would have to surrender draft-pick compensation. As a revenue-sharing recipient, the Brewers will surrender their third-highest pick in the draft. The qualifying offer slightly diminished Grandal’s value, but qualifying offers are far from the only — and far from the greatest — issue conspiring against free agents. Even after last winter’s lack of free-agent activity, Grandal likely expected that he would be able to do much better than the deal he got. He not only turned down the Los Angeles Dodgers’ qualifying offer earlier in the offseason, but he also reportedly rejected a four-year, $60 million offer from the New York Mets.Instead, Grandal becomes the latest free agent to receive far fewer dollars and years than he had initially sought.The average salary in baseball declined last year for just the fourth time in the past 50 years and the first time since 2004, according to the Associated Press.Through Wednesday, the 73rd day of this offseason, 10.2 percent of available free agents2Our pool of available free agents includes any player with major league experience who was granted free agency or released in October and November of each season. That excludes players signed internationally or those waived by a club before the season ended or later in the offseason. had signed for a total of $856.2 million, according to a FiveThirtyEight analysis of data from The Baseball Cube. While that’s an improvement over the same point of last offseason, when only 6.5 percent of free agents had signed for $550.5 million, the total dollars spent to date are still down from 2016-17 ($1.017 billion through Day 73), 2015-16 ($1.697 billion), 2014-15 ($1.308 billion) and 2013-14 ($1.452 billion).And the share of free agents signed is trending above the past two offseasons, but it’s still trailing the previous three: As the free agency landscape changes, some teams seem to be looking for openings to give them an edge. Grandal has been the Brewers’ only guaranteed free-agent signing so far,3They have also reportedly agreed to a split deal with pitcher Jake Petricka, meaning that the contract would depend on whether he makes the big-league club. but it’s a significant addition in their quest to repeat as National League Central champs.Sara Ziegler contributed research.
The Ohio State baseball team (24-20, 8-10 Big Ten) is making a run for the Big Ten tournament – literally. OSU was eighth in the Big Ten as of Wednesday and one-and-a-half games behind Nebraska, Michigan State, Penn State and Illinois, all tied for fourth place in the Big Ten. The eighth-place Buckeyes are trying to steal their way back into the race for sixth place and qualify for the Big Ten tournament. The Buckeyes have been tearing up and down the base paths so far in 2012, and were third in the Big Ten in stolen bases as of Wednesday, according to bigten.org. OSU, with 17 stolen bases, is just seven behind Big Ten leader, Illinois. The Buckeyes have blown past their base-stealing pace from last season, in which OSU tallied 35 total steals in all competitions. Players and coaches alike said stealing bases is important to a team’s offense and has multiple benefits. “Stolen bases help us out a lot as hitters,” said sophomore center fielder Tim Wetzel. “It gives us RBI chances and the whole point of the game is to score runs. And as a defense, when a team runs on you, you can’t be as loose because you have guys running around. It just helps the flow of the game and helps the offense perform.” OSU coach Greg Beals said stolen bases can influence a game and throw off an opposing defense. “As a catcher, I have a great understanding of what (a stolen base) does to an opponent’s defense,” Beals said. “What it does to pitch calling and what it does on the field, taking away from double play opportunities. It does a lot for you offensively and affects their defense quite a bit.” Beals said he likes having the ability to steal bases, but a team needs the right personnel to do so. Of the team’s 68 overall steals, 23 have come from junior infielder Kirby Pellant, a transfer in his first year with OSU. “You have to take advantage of every little opportunity to steal a base” said Pellant, the starting shortstop. “Stolen bases are a big part of the game. If you hit a single and steal a bag, it becomes a double. When you can get one to start an inning it gets the whole team going.” Wetzel, who has 10 stolen bases in 2012, said it’s important for a team to be in sync before a steal. “We talk about it a lot if we think we have a good read on a (pitcher),” Wetzel said. “Second time through, we’ll talk it out and say, ‘First pitch I’m going,’ so we’ll just know to take and let him steal a bag.” OSU’s next game is Friday at home at 7 p.m. at Nick Swisher Field at Bill Davis Stadium against Northwestern, the first game of a three-game weekend series with the Big Ten opponent.
Junior quarterback Braxton Miller (5) avoids a group of defenders during a game against Wisconsin Sept. 28 at Ohio Stadium. OSU won, 31-24.Credit: Shelby Lum / Photo editorFor the briefest of moments, coach Urban Meyer wasn’t sure what the future held for his starting quarterback, Braxton Miller.Miller was at the end of his junior season and potentially off to the NFL, leaving Meyer in search of a new starter.But that feeling of uncertainty didn’t last.“It wasn’t very long … Braxton and I have a very good relationship,” Meyer said Feb. 5 at National Signing Day. “We waited until after the (Orange Bowl). And I told him my opinion that he could become a very high draft pick if he continues to improve, and he said, ‘That’s what I thought.’ It wasn’t much more than that. We met together as a family. Had a very positive conversation and made the decision. Never at one time (did he) say, ‘What should I do?’ Because I wouldn’t tell him. That’s their business. But I gave my opinion as far as how much he could grow as a quarterback.”Miller didn’t have the same hesitation as his coach, and was confident he would come back.“I always knew I was going to eventually make that decision and I was going to come back,” Miller said Wednesday.The junior quarterback said his decision was easy because he still had things he needed to do for OSU.“Getting a degree, things like that,” Miller said. “You want to accomplish things that you didn’t accomplish in your first three years so I felt like I left little things on the field … it’s a lot of things I think about and that’s why I wanted to come back.”Miller announced his decision to return to Ohio State for his senior season Jan. 9 after compiling a 28-8 record in his first three seasons at the helm for the Buckeyes.The two-time defending Big Ten offensive player of the year, Miller’s versatility as a player isn’t lost on anybody involved with OSU football.“To replace a dynamic (player) like a Braxton Miller, what he can do with the football, with his feet, it’s thinning the play, those are all kinds of things that are not coached,” running backs coach Stan Drayton said Feb. 5. “A lot of what he does is not coached. That would have been devastating. Not to say that we would not have survived the moment … What he brings to the table is something special, and it would have been dearly missed.”Miller heads into the 2014 season as OSU’s eighth all-time leader in rushing yards, and he needs 715 yards to pass Eddie George and take over the second spot on that list. Coincidentally, Miller amassed exactly that many yards on the ground in 2011, the least productive rushing season he has had as a Buckeye.As long as Miller does not seriously regress as a ball carrier next season, eclipsing George’s career total of 3,768 yards should be an attainable feat.He is also eighth all-time on the career passing yardage list. If Miller can accomplish his third consecutive year of passing for at least 2,000 yards, he would surpass Bobby Hoying for second place and would be within striking distance of Art Schlichter’s record of 7,547 yards.Although the offense does return five starters — Miller, sophomore offensive lineman Taylor Decker, junior wide receivers Devin Smith and Evan Spencer, and junior tight end Jeff Heuerman — it loses four starting linemen, something that could play a big role in determining Miller’s success next season.“Now, Braxton Miller also did those things behind four veteran offensive linemen,” Drayton said. “To me, that’s the issue that we think about in that war room there, is how we put five guys in front of him where he can feel comfortable. We know he’s going to continue to develop and mature in his growth toward the game. However, we’ve got to put some guys around him where he’s feeling comfortable.”One of the biggest beneficiaries of Miller’s decision to stay in school is the corps of Buckeye wide receivers. During his career at OSU, Miller has attempted 668 passes, while all other quarterbacks on the current roster have a combined two attempts.Even though the receivers would have been fine no matter who was under center, wide receivers coach Zach Smith said having Miller’s experience returning is a big boost for the unit.“It’s huge. Braxton’s a great player and my guys love Braxton taking the snap,” Zach Smith said. “We’re confident with whoever the quarterback is but having a guy like Braxton that, one, is as talented a quarterback I’ve ever seen and two, if a play’s not there — my guy isn’t open, whatever it is — he can keep a play alive. The number of big plays that come from Braxton Miller’s feet and throwing the ball in a scramble situation … my guys love that.”Herman added that although a lot of what Miller brings back is positive it isn’t all going to be easy for the quarterback.“As improved as he got on the mental side of play of quarterback he can still get a whole lot better,” Herman said Wednesday. “He can make the same leap this year and still have work to do. So just the confidence, the studying of the game, studying of defenses and studying of our plays now that we’ve done kind of the same thing two years in a row.”Miller is set to get his next crack at the field Aug. 30 when OSU is scheduled to play Navy at M&T Bank Stadium in Baltimore.
The sculptor Emanuel Jorge da Silva Santos has recreated his iconic Cristiano Ronaldo sculpture that caught the attention of the whole world last yearIn honour of their Real Madrid star, Madeira’s Fuchal Airport was renamed the Cristiano Ronaldo Madeira International Airport with a bust having been made for the legendary forward, who captained Portugal to the Euro 2016 trophy.Ronaldo, who attended the opening ceremony of this special event, was presented with a bronze bust of his face, that quickly went viral on the internet with British comedian James Corden famously saying: “It looks like his face was bended like Beckham!”But Bleacher Report has now recently tracked down Silva Santos and convinced the now-famous sculptor to give it another try.29.03.2017 vs. 29.03.2018Emmanuel Santos’ shot at redemption. pic.twitter.com/A91RjDJCOF— B/R Football (@brfootball) 29 March 2018Fiorentina owner: “Ribery played better than Ronaldo!” Andrew Smyth – September 14, 2019 Fiorentina owner Rocco Commisso was left gushing over Franck Ribery’s performance against Juventus, which he rates above that of even Cristiano Ronaldo’s.The new version certainly looks to be an improvement, but Ronaldo did make one last request for the sculptor before unveiling to the world.“[Ronaldo’s] smile is ripped to the left side.” the sculptor told Bleacher Report“As we know, Ronaldo is vain. He likes to be all groomed up!“When they tried it they—instead of thinning them out slightly—added a few strokes so [as] to conceal the wrinkles. It wasn’t a detail of great relevance and it didn’t change much of the wrinkles it had.”Following a difficult start to the season, Ronaldo has had a resurgence of his own at Real this season with the Portuguese star having scored 21 goals in his last 11 appearances for the club.
Marcel Desailly has backed the inexperienced France squad to cause a surprise in the upcoming World Cup in RussiaLes Bleus somewhat struggled in the qualifying stages of the World Cup and have been drawn against the likes of Australia, Peru and Denmark in Group C for this summer’s tournament.But Desailly, who himself won the 1998 World Cup with France, is convinced that they have the quality to do well in the tournament and believes that their opponents in Group C will be relatively easy compared to the rest of the competition.“They have quality but not the experience, so we hope that the group stage, which is apparently not that difficult, will allow them to build up the confidence that they need,” said the 49-year-old, according to Gulf News.“When you top up confidence plus talent you hope that yes, France will now surprise everyone.Opinion: Neymar will earn respect back from the PSG fans Tomás Pavel Ibarra Meda – September 14, 2019 After completing his incredible return to Parc des Princes, we predict that Neymar will earn the respect back from PSG supporters.The situation between Neymar…“They surprised us during the Euros when we were not sure they were capable of reaching the final, and they almost won, so maybe they can do the same with the World Cup.“We need a win, it’s been too long. It’s the 20th anniversary of us winning the World Cup, so it would be good if they could win it this year.”France previously finished as the runners-up in Euro 2016, but Desailly warned that a lot has changed since then and fears that team boss Didier Deschamps is yet to find a system to properly utilise the new players in the squad.“We’ve lost all confidence built up during the Euros, we’ve lost our left and right backs in defence (Patrice Evra and Bacary Sagna have retired from international football), and we have new players who have to adapt to each other. Didier Deschamps doesn’t really know about his tactical set-up or his philosophy, so there’s quite a lot of work to do.” said the former Chelsea defender.“The Euros are gone and now you are starting a new movement. You can say they are ready for the next Euros hoping maybe that they are going to surprise everybody at the World Cup — that is the position of France.”