Tags More about 2018 Volkswagen Golf GTI Review • 2018 Volkswagen Golf GTI: The daily-driver hot hatch 1 2020 Mini JCW Clubman first drive: A fast alternative for the crossover-averse 2020 Mercedes-Benz GLC-Class first drive: If it ain’t broke… More From Roadshow Share your voice 2020 Bentley Continental GT: Concept looks with a surprise inside Comment Volkswagen Originally, it was believed that Volkswagen would introduce the eighth generation of its venerable Golf at the Frankfurt Motor Show in September. Now, it appears that won’t be the case, as delays have beset VW’s compact car.Software issues have pushed back the unveiling of the eighth-generation VW Golf, Automotive News Europe reports, citing an interview with board member Jürgen Stackmann at the Shanghai Motor Show. “We’ve never hid the fact that software, an area of extreme importance for products in the future, is a serious challenge for us,” Stackmann told ANE. “We have our homework ahead of us, and the teams are under heavy pressure.”Specifically, ANE’s report highlights one area where it’s taking some time to get the software right — over-the-air (OTA) updates. This new kind of vehicle update allows an automaker to beam patches and possibly even new features directly to a vehicle, instead of requiring it to return to the dealer for a physical update. Stackmann specifically pointed to OTA security and homologation requirements in various markets when ANE asked about specific instances causing the delay.Enlarge ImageIt’s not the newest compact on the block, but the seventh-generation Golf is still a compelling buy in the US, offering solid build quality on a platform that’s rewarding to drive. Volkswagen “You’re adding content to a vehicle afterwards, and this is an area where we are working together with the type approval agencies to define these processes. It is new for them as well,” Stackmann told ANE.The issues will allegedly affect the beginning of the eighth-gen Golf’s production, too. Germany’s Der Spiegel reported earlier this month that, instead of building 80,000 Golfs this year as planned, VW will build about 10,000. VW confirmed this move to Der Spiegel, but nevertheless, the automaker remains on target to have the cars on sale in Germany on or around Feb. 24 of next year, with the rest of Europe to follow. The US generally receives a new Golf about a year after the Europeans do, so hopefully VW hammers out all those bumps well ahead of its stateside debut.In lieu of a new Golf to display in Frankfurt, Volkswagen will instead reveal the production version of the ID electric hatchback, which ANE first reported this March. The ID hatch, which might be called the ID Neo, will be Europe’s first foray into Volkswagen’s new all-electric lineup. In the US, that honor will go to the ID Crozz crossover. Hatchbacks Future Cars
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Google Nest Hub: $59 (save $70) Tags Turo is kind of like Uber meets Airbnb: You borrow someone’s car, but you do all the driving. I’ve used it many times and found it a great alternative to traditional car-rental services — in part because you get to choose exactly the vehicle you want (not just, say, “midsize”) and in part because you can often do pickup and dropoff right outside baggage claim.Between now and Sept. 1, the first 300 people to check out can get $30 off any Turo rental with promo code LDW30. Read DJI Osmo Action preview Amazon Recently updated to include digital-photo-frame capabilities, the Lenovo Smart Clock brings Google Assistant goodness to your nightstand. It’s a little smaller than the Amazon Echo Show 5, but also a full $30 less (and tied with Prime Day pricing) during this Best Buy Labor Day sale. Read the Rylo camera preview Lenovo Smart Clock: $59.99 (save $20) Turo: Save $30 on any car rental An Echo Dot makes a fine match for any Fire edition TV, because you can use the latter to say things like, “Alexa, turn on the TV.” Right now, the 24-inch Insignia Fire TV Edition starts at just $100, while the 32-inch Toshiba Fire TV Editions is on sale for $130. Just add any Fire TV Edition to your cart, then add a third-gen Echo Dot, and presto: The latter is free. Tidal 3-month family subscription: $5.99 (save $54) DJI’s answer to GoPro’s action cameras is rugged little model that’s shockproof, dustproof and waterproof down to 11 meters. It normally runs $350, but this deal drops it to $261 when you apply promo code 19LABOR10 at checkout. Rylo Spotify and most other streaming services rely on compressed audio, which robs the listener of full fidelity. Enter Tidal, the only “major” service that delivers lossless audio — meaning at least on par with CD quality, if not better. Want to see (er, hear) the difference for yourself? Grab this excellent extended trial while you can. It’s just $6 for three months, and it’s good for up to six listeners. Read Lenovo Smart Clock review See It $60 at Best Buy Rylo 5.8K 360 Video Camera: $250 (save $250) Free Echo Dot with an Insignia or Toshiba TV (save $50) $999 Read the AirPods review Sarah Tew/CNET HP Laptop 15t Value: $520 (save $780) See it Review • iPhone XS review, updated: A few luxury upgrades over the XR See at Turo $90 at Daily Steals via Google Express Chris Monroe/CNET The problem with most entry-level laptops: They come with mechanical hard drives. That makes for a mighty slow Windows experience. This Lenovo model features a 128GB solid-state drive, so it should be pretty quick to boot and load software, even with its basic processor. Plus, it has a DVD-burner! That’s not something you see in many modern laptops, especially at this price. Share your voice Preview • iPhone XS is the new $1,000 iPhone X Read Google Home Hub review Tags $299 at Amazon Comments $210 at Best Buy Best laptops for college students: We’ve got an affordable laptop for every student. Best live TV streaming services: Ditch your cable company but keep the live channels and DVR. 7 Best Buy Phones 0 Sarah Tew/CNET See at Amazon $520 at HP See It Cricket is launching a new ad-based rewards program. Cricket Wireless Cricket Wireless and mobile rewards developer Adfone are rolling out a rewards app and program called Ad It Up, the companies said Tuesday. Using the app, Cricket Wireless customers across the US can choose to view ads on their phone and, in return, earn points that can be redeemed for bill credits. The Ad It Up app will come “preloaded on millions of select Cricket Android phones,” the companies said, but customers can choose to opt in or out from their devices. When customers register for the program, they’ll be asked to choose their interests so the program can show them targeted ads. “This deployment represents a sizable opportunity for both advertisers reaching Cricket customers as well as telecom companies looking to build and generate revenue in revolutionary ways,” Adfone CEO Brian Boroff said in a release. What’s cooler: A snapshot of a firework exploding in front of you, or full 360-degree video of all the fireworks and all the reactions to seeing them? Oooh, ahhh, indeed. At $250, the compact Rylo dual-lens camera is selling for its lowest price yet. And for an extra $50, you can get the bundle that includes the waterproof housing.This deal runs through Sept. 3; it usually costs $500. The Cheapskate $6 at Tidal $155 at Google Express Sarah Tew/CNET Sprint CNET may get a commission from retail offers. Formerly known as the Google Home Hub, Google’s Nest Hub packs a wealth of Google Assistant goodness into a 7-inch screen. At $59, this is within a buck of the best price we’ve seen. It lists for $129 and sells elsewhere in the $89-to-$99 range.This is one item of many available as part of eBay’s Labor Day Sale (which, at this writing, doesn’t specifically mention Labor Day, but that’s how it was pitched to us). JBL Soundgear wearable speaker: $90 (save $160) $999 Apple iPhone XS Post a comment Sarah Tew/CNET $59 at eBay Mentioned Above Apple iPhone XS (64GB, space gray) Cricket,I’m shocked — shocked! — to learn that stores are turning Labor Day into an excuse to sell stuff. Wait — no, I’m not. As much as I respect the original intent of the holiday (which became official back in 1894), to most of us, it’s just a bonus day off — one that’s blissfully tacked onto a weekend. So, yeah, stores; go ahead, run your sales. I’m listening. Perhaps unsurprisingly, Labor Day doesn’t bring out bargains to compete with the likes of Black Friday (which will be here before you know it), but there are definitely some sales worth your time.For example:We’ve rounded up the best Labor Day mattress deals.We’ve also gathered the best Labor Day laptop deals at Best Buy.The 2019 Vizio P Series Quantum is back under $999.Be sure to check out Amazon’s roughly three dozen Labor Day deals on TVs and audio. Google Express is having a big sale as well, one that includes deals on game consoles, AirPods, iPhones, laptops and more.Below I’ve rounded up a handful of individual items I consider to be the cream of the crop, followed by a handy reference guide to other Labor Day sales. Keep in mind, of course, that products may sell out at any time, even if the sale itself is still running. Note that CNET may get a share of revenue from the sale of the products featured on this page. Though not technically a Labor Day sale, it’s happening during Labor Day sale season — and it’s too good not to share. Nationwide Distributors, via Google Express, has just about the best AirPods deal we’ve seen (when you apply promo code ZBEDWZ at checkout). This is for the second-gen AirPods with the wireless charging case. Can’t imagine these will last long at this price, so if you’re interested, act fast. $999 Use promo code 19LABOR10 to get an unusually good deal on JBL’s interesting hybrid product — not quite headphones, and not quite a traditional speaker, but something you wear like neckphones to listen to music on the go. See It I thought this might be a mistake, but, no, the weirdly named HP Laptop 15t Value is indeed quite the value at this price. Specs include an Intel Core i7 processor, 12GB of RAM, a 256GB solid-state drive and a 15.6-inch display. However, I strongly recommend paying an extra $50 to upgrade that display to FHD (1,920×1,080), because you’re not likely to be happy with the native 1,366×768 resolution. Apple AirPods with Wireless Charging Case: $155 (save $45) Lenovo 130-15AST 15.6-inch laptop: $210 (save $90) $261 at Daily Steals via Google Express Share your voice Other Labor Day sales you should check out Best Buy: In addition to some pretty solid MacBook deals that have been running for about a week already, Best Buy is offering up to 40% off major appliances like washers, dryers and stoves. There are also gift cards available with the purchase of select appliances. See it at Best BuyDell: Through Aug. 28, Dell is offering an extra 12% off various laptops, desktops and electronics. And check back starting Aug. 29 for a big batch of Labor Day doorbusters. See it at DellGlassesUSA: Aug. 29 – Sept. 3 only, you can save 65% on all frames with promo code labor65. See it at GlassesUSALenovo: The tech company is offering a large assortment of deals and doorbusters through Labor Day, with the promise of up to 56% off certain items — including, at this writing, the IdeaPad 730S laptop for $700 (save $300).See it at LenovoLensabl: Want to keep the frames you already love and paid for? Lensabl lets you mail them in for new lenses, based on your prescription. From now through Sept. 2 only, you can save 20% on the blue light-blocking lens option with promo code BLOCKBLUE. See it at LensablSears: Between now and Sept. 7, you can save up to 40% on appliances (plus an additional 10% if you shop online), up to 60% on mattresses, up to 50% on Craftsman products and more. The store is also offering some fairly hefty cashback bonuses. See it at SearsNote: This post was published previously and is continuously updated with new information.CNET’s Cheapskate scours the web for great deals on tech products and much more. For the latest deals and updates, follow the Cheapskate on Facebook and Twitter. Questions about the Cheapskate blog? Find the answers on our FAQ page, and find more great buys on the CNET Deals page. DJI Osmo Action camera: $261 (save $89) TVs Speakers Mobile Accessories Cameras Laptops Automobiles Smart Speakers & Displays Boost Mobile Angela Lang/CNET $999 Turo
The Brencore Allstars perform Motown hits from the 1960s and ‘70s. (Courtesy Photo)The Publick Playhouse, in Cheverly, Maryland, served as a time travelling machine on the night of Sept. 26, as it took audiences back to the 1960s and 70s, with Motown hits played during the Tribute to the Music of Motown by the Brencore Allstars.The Brencore Allstars are a local 12-piece band from the Washington, D.C. area.“I personally think this is the best Motown revue on the east coast,” Robert Smoot, CEO of Brencore Entertainment and producer of the show, said. He said he compared the show’s quality to Motown the Musical on Broadway.Six singers, in the show, did a compilation of full songs of classic Motown artists, and a host of medleys, from singers such as Smokey Robinson, The Four Tops, Marvin Gaye and Tammi Terrell, The Temptations, The Supremes, and The Jackson 5.Not only did they sing, Motown hits, but the show also paid homage to Aretha Franklin, who is known as the queen of soul.The performances were interactive as they encouraged audience members to get out their seats and dance. Smoot said the show’s interactive nature was what made it different from other Motown revue performances.“Come on miss lady with those cute earrings I like,” sang Lakesha Ameya Taylor, directly to an audience member who was flattered and danced even harder.Linda Lewis, an audience member who came to the show as a birthday gift to her 97-year-old husband, Harvey Lewis, thoroughly enjoyed the show. “I think it’s important because it made you move,” she said.In total, there were 28 songs performed by the band.Brencore Allstars will perform a Tribute to the Music of Motown next at the Howard Theatre on Nov. 15 at 7:30 p.m.
Ball-and-stick model of lincomycin. Credit: Jynto/Wikipedia Journal information: Nature Scientists study how marine bacteria release cloud-making compound Citation: Researchers unravel the elusive source of sulfur in an antibiotic (2015, January 15) retrieved 18 August 2019 from https://phys.org/news/2015-01-unravel-elusive-source-sulfur-antibiotic.html Explore further More information: Metabolic coupling of two small-molecule thiols programs the biosynthesis of lincomycin A, Nature (2015) DOI: 10.1038/nature14137AbstractLow-molecular-mass thiols in organisms are well known for their redox-relevant role in protection against various endogenous and exogenous stresses1, 2, 3. In eukaryotes and Gram-negative bacteria, the primary thiol is glutathione (GSH), a cysteinyl-containing tripeptide. In contrast, mycothiol (MSH), a cysteinyl pseudo-disaccharide, is dominant in Gram-positive actinobacteria, including antibiotic-producing actinomycetes and pathogenic mycobacteria. MSH is equivalent to GSH, either as a cofactor or as a substrate, in numerous biochemical processes4, most of which have not been characterized, largely due to the dearth of information concerning MSH-dependent proteins. Actinomycetes are able to produce another thiol, ergothioneine (EGT), a histidine betaine derivative that is widely assimilated by plants and animals for variable physiological activities5. The involvement of EGT in enzymatic reactions, however, lacks any precedent. Here we report that the unprecedented coupling of two bacterial thiols, MSH and EGT, has a constructive role in the biosynthesis of lincomycin A, a sulfur-containing lincosamide (C8 sugar) antibiotic that has been widely used for half a century to treat Gram-positive bacterial infections6, 7, 8, 9. EGT acts as a carrier to template the molecular assembly, and MSH is the sulfur donor for lincomycin maturation after thiol exchange. These thiols function through two unusual S-glycosylations that program lincosamide transfer, activation and modification, providing the first paradigm for EGT-associated biochemical processes and for the poorly understood MSH-dependent biotransformations, a newly described model that is potentially common in the incorporation of sulfur, an element essential for life and ubiquitous in living systems. As Melancon notes, there are a host of molecules vital for biological processes that have sulfur as a component—their metabolic origins can be predicted as a matter of course. Sulfur atoms on the other hand have been much more difficult to predict. Overcoming such obstacles for some molecules could have benefits such as helping to develop new medicines. In this new effort the researchers set their sights on lincomycin A, an antibacterial agent that has been used to treat Gram-positive bacterial infections for many years.To find the sulfur source, the researchers used modern whole genome sequencing techniques to work backwards through likely pathways looking to isolate intermediaries that tended to build up as genes were disrupted. Doing so led to the discovery that disruption of lmbE led to intermediates that looked a lot like lincomycin—that led them to study lambV, a gene that also shows up in lincomycin, which led to the discovery of another intermediary. The team also tested other enzymes and found a way to prove that there were at least three of them that incorporated sulfur into parts of the antibiotic, which was the original goal, of course. More specifically, they found that two bacterial thiols played a constructive role in the biosynthesis of lincomycin A. The team then went further, isolating the materials that were produced due to the genes involved, along with the functions of enzymes that were part of the process.Work done by the team should help provide a pathway for other researchers attempting to find the source of sulfur atoms in other molecules, perhaps leading to new types of materials for use in a variety of medical purposes, from antibiotics to cancer fighting agents. © 2015 Phys.org (Phys.org)—A team of researchers working at the Chinese Academy of Sciences in Shanghai has for the first time found the source of sulfur atoms in lincomycin A, a lincosamide widely used as an antibiotic agent. In their paper published in the journal Nature, the team describes their research efforts and results. Charles Melancon with the University of New Mexico outlines and comments on the work done by the team in the same journal issue. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
7 min read Hear from business owners and CEOs who went through a crippling business problem and came out the other side bigger and stronger. Considering the runaway success of the app market, it’s easy to understand why many founders think their paths to unicorn status runs through App City. While some pundits were digging an early grave for apps, Apple was busy breaking records. The company’s App Store experienced its busiest day in history on Jan. 1 of this year, notching nearly $240 million in sales.This single-day surge represents another spike in the expanding app marketplace. In 2016, developers earned more than $20 billion through the Apple App Store — a 40 percent increase from 2015 earnings. For some historical perspective, developers have earned $60 billion in total since the app store launched in 2008.These gaudy sales figures add to the lure of app development as the latest panacea for startups.While it might be relatively cheap, easy and fast to produce an app, these low barriers to entry are misleading. Too many founders rely on apps alone to drive profits, ignoring traditional business wisdom in the process.Even if a company develops a market-disrupting app that reinvents smartphone use, developing the tech and tossing it onto the app store without any sort of strategy will likely lead to failure. Whether you’re producing an app or opening a new brick-and-mortar store, your venture still needs plenty of marketing, positioning and customer service.Simply put, businesses cannot thrive on apps alone.Thinking beyond the appI’ve seen this app-happy mindset in my entrepreneurship classes, which involve students working over the course of a semester to create business ideas that solve real-world problems. These young minds regularly see creating an app as the perfect solution, typically replacing an existing service or marginal problem such as finding cheap insurance or locating a nearby gas station with a smartphone app.The bulk of these app-driven solutions attempt to emulate the success of OpenTable, the online restaurant reservation app. This approach frequently involves adding a dash of digital convenience to existing physical infrastructure.This sort of digital window-dressing on the real world drove the initial dot-com boom of the ’90s. The main issue with this line of thinking during the Cretaceous period of the internet is the same problem driving the app-first approach of today: By creating a digital link to an established brick-and-mortar industry, you’re tying yourself down to the present. This also makes your company susceptible to anything that might disrupt the physical side of your industry.Instead of a tie to the present or past, entrepreneurs need to use their vision and intellect to think beyond the curve and lasso the future of a given market.Related: 5 Situations When Building an App Is Just a Dead EndThe app of your dreamsInnovation in the digital age isn’t about using technology to improve existing experiences; true innovation involves completely exploding the current model. The best solution to one of society’s woes could very well be an app — Uber, Kindle and Tinder have completely disrupted their respective industries — but consider the strategy behind your app before sending your creation into the wild.1. Remain grounded in reality. The pizza industry is firmly rooted in the real world, with a reliance on physical ovens, ingredients and delivery drivers. Despite this reliance, pizza juggernaut Domino’s has relentlessly tinkered with technology in a quest to simplify the ordering experience.The company started with a mobile app that allows customers to bypass phone calls and website visits to order pizza. That’s great, but Domino’s took things a step further by creating a tweet-to-order system and experimenting with ordering via text messages and emojis. Most recently, the company made it possible to order directly from an Amazon Echo. The next time you want a supreme pizza, Alexa has you covered.Related: Domino’s Now Makes Pizza Deliveries Via Military RobotThis trailblazing in the digital world appears to be paying off. The pizza company’s endeavors drove 50 percent of U.S. sales in 2015, according to TechCrunch, with Domino’s bringing in $4.7 billion from digital ordering channels worldwide.Domino’s provides a road map for how apps can drive value, but only when they integrate as seamlessly as possible with the real world. Apps that deliver a way to track, follow up and manage existing processes create value by essentially giving users a remote control for the economy.Apps should not be digital veneers masking traditional behavior. Instead, they should spur a change in fundamental consumer behavior.2. Everything has its limits. Even the digital universe of apps has some boundaries. Aside from the need to upgrade and maintain apps, developers must deal with barriers between existing platforms.iOS has traditionally been the more lucrative platform for developers, with many apps appearing on Apple devices before other platforms. In particular, a lot of mobile games land on iOS first before branching out to Android devices. “Super Mario Run,” which generated about $53 million for Nintendo, launched on iOS in December but and on Android devices in March.Related: 4 Ways to Avoid Nintendo’s Super Mario Mobile MistakeWhile Apple still dominates the U.S. scene, Android is carving out a larger market share elsewhere. Android has gained some traction because it benefits from the latest versions of Google’s apps and the Google Play store has a higher percentage of free apps than the Apple app store.Be mindful of the strengths and weaknesses of various platforms. While it’s possible to launch on several platforms at once, you’ll also risk being a jack-of-all-trades and master of none. Developing an app for these different devices simultaneously can quickly increase your expenses and time to market.3. The end should justify the means. This might sound like heresy, but consider whether people even need an app to solve the problem your business is targeting. Will they need a solution to your problem with regularity? That will determine how frequently they use your app. Will your customers find your proposed solution valuable? This answer should tell you everything you need to know.An emerging business needs a “yes” answers to both of those questions for an app to make sense. Having a great app should not be your goal. Instead, focus on adding value to the customer through a great app.The value you deliver should justify the cost rather than the other way around. An app that’s cheaper than the alternative isn’t necessarily a better tool for users. Creating a half-baked app could destroy value in the end, so focus on the value you want to create rather than the cost it takes to get there. That’s the only way to justify any business decision, including app development.Software is indeed eating the world — as Marc Andreessen opined back in 2011 — but not by digitizing existing functions. The true power of software lies in changing behaviors through sidestepping physical limitations that dictate much of what we do today.It’s unclear whether we’ve seen the apex of apps, but all the sales records in the world are useless without a clear and beneficial connection with the physical world. Founders cannot succeed by trying to substitute technology for business skills and market knowledge. There is no app for that. Listen Now Problem Solvers with Jason Feifer March 20, 2017 Opinions expressed by Entrepreneur contributors are their own.