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Thirty-eight and no: Wisconsin moves on to national championship game with stunning win over undefeated Kentucky

first_imgINDIANAPOLIS – The Wisconsin men’s basketball team was able to do something no other team has done all season.No other team this season had beaten the Kentucky Wildcats but Saturday night at Lucas Oil Stadium, in perhaps the biggest game in program history on the game’s biggest stage, Wisconsin found a way to stop the Wildcats pursuit of a perfect 40-0 season dead in its tracks.And by doing so, the Badgers are moving on to the national championship game for the first time in 74 years and just the second time in program history as Wisconsin knocked off Kentucky 71-64 Saturday night.Wisconsin (36-3) will take on the No. 1 seed in the South Region, Duke (34-4), on Monday in the national title game.“I think that loss last year motivated us through the off-season so we could get back here,” Wisconsin senior forward and AP Player of the Year Frank Kaminsky said. “Once the season started, we had our own goals in mind. It’s great we had a chance to play a good team along the way and come out on top.”After a back-and-forth first half, Wisconsin was able to take the lead for the majority of the second half before going on an untimely 6:08 scoring drought in the middle of the half. Kentucky (38-1) came back during that stretch to take a 60-56 lead with 6:36 left in the game. It was Wisconsin’s largest deficit of the half.But Wisconsin then locked down on defense, forcing Kentucky into three straight shot clock violations before Sam Dekker hit a 3-pointer from the top of the key that gave the Badgers the lead back, 63-60, with 1:42 remaining.“Those shot clock violations were big for us,” Wisconsin junior forward Sam Dekker said. “Gave us confidence on the defensive end and maybe hopefully drained a little bit of their confidence on the offensive end.”Dekker turned right around on defense after the three and drew perhaps the biggest charge of the season with 1:25 remaining as Kentucky’s Trey Lyles was called for the offensive foul.“Him being down low, Sam saw the opportunity of him trying to bully his way to the rim. He made a great play for us,” Wisconsin sophomore forward Nigel Hayes said of Dekker’s charge.Wisconsin got the ball back after the Kentucky offensive foul and Dekker converted a free throw on the other end to extend the Badgers’ lead to four at 64-60 with 1:06 left in the game.Aaron Harrison answered for Kentucky with a jumper but Wisconsin closed the game out by going 7-for-8 from the free-throw line over the final minute of play. One last 3-point attempt from Harrison that would have kept Kentucky in the game missed everything with five seconds left and sealed the Badgers’ school record 36th win and a matchup with Duke on Monday in the national title game.Kaminsky led Wisconsin on Saturday scoring a game-high 20 points (7-for-11) with 11 rebounds while Dekker added 16 points on 6 of 9 shooting.Michael Reaves/Kentucky KernelKnown for being one of the best rebounding teams in the country, Kentucky was outrebounded by Wisconsin 34-22 including a 12-6 advantage on the offensive glass. The Badgers turned those 12 offensive rebounds into 13 second change points.“We just tried to do whatever we could to stay into them,” Kaminsky said. “We know if they get another offensive rebound, they get another chance to score. They’re such a good offensive team, if they get buckets that way, it’s going to be a long night.”Karl-Anthony Towns paced Kentucky with 16 points and nine rebounds while Andrew Harrison (13) and Aaron Harrison (12) rounded out the Wildcats in double figures on Saturday night. All-American Willie Cauley-Stein scored only two points on 1 of 4 shooting for Kentucky.After shooting 60 percent (15-for-25) in the first half, Kentucky shot only 37.9 percent (11-for-29) in the second half. Wisconsin shot 47.9 percent (23-for-48) for the game and went 7-for-17 (41.2 percent) from beyond the arc.But like they’ve grown accustom to, the Badgers never wavered when they saw their lead switch into Kentucky’s favor. It’s arguably the most important reason why Wisconsin will be playing for its second championship in program history on Monday.“We know the type of team we have,” Dekker said. “We know the type of coaching staff we have. We know that whatever is going on in the game, we’re not going to change.“Whether we’re down six or up 20, we’re going to be us and we’re going to play our game.Michael Reaves/Kentucky KernelAnd with just a day separating Saturday’s win and Monday’s game, the celebration time will be short as Wisconsin will prepare to defeat a Duke team who it previously lost to this season in an 80-70 defeat at the Kohl Center in December.“It’s not over. We have nothing to celebrate,” Wisconsin fifth-year senior Josh Gasser said. “We obviously won a great game, it’s a huge accomplishment making it to the national championship game, but it wasn’t our goal to make it to the national championship. So we celebrated for a good five, six seconds and then we have to move on.”last_img read more

All a good party needs is witty Jennifer Tilly

first_img AD Quality Auto 360p 720p 1080p Top articles1/5READ MOREStriving toward a more perfect me: Doug McIntyre With the strong reviews for “Intervention,” might there be another chance at Oscar? “I never thought I was going to become major, major,” she said. “The Oscar nomination came out of nowhere. I did my own little campaign. I did my own ads. Overnight, I had the paparazzi, who would take pictures of me if I hung around long enough looking hopeful. Once in a while, `Entertainment Tonight’ would ask me something if no one was around. Then everyone wanted my opinion about everything! It was hard to realize my social status had changed.” Jennifer is best known for her comic roles, in films such as “Bullets” and “Liar Liar,” and as the voice of Bonnie Swanson on “Family Guy,” but “Intervention” gives her a chance to show her dramatic chops. She plays a woman confronting the possible disintegration of her marriage as her husband goes through drug rehabilitation. “I do a lot of comedy. Comedy is fun, and I like to make people laugh. This entire movie was improvised, and everyone came up with their own characters. When I’m faced with that situation, I like to come up with the kind of character no one casts me as.” Once famously dubbed the hardest-working actress in Hollywood, she has six films in the can waiting for release. One of them is “Silver Valley,” which Jennifer amusingly describes as “the most expensive movie China ever made.” Interviewing Jennifer Tilly is a lot like being at a really good party: You hear lots of great stories, you laugh a lot, and it all ends far too soon. All I needed was a drink! Jennifer was calling from Puerto Vallarta to talk up her movie “Intervention,” which won Best Feature honors at the San Diego Film Festival last month and earned Jennifer the Best Actress prize. “Actors – we always love to get awards,” admits Jennifer, nominated for an Oscar for Woody Allen’s “Bullets Over Broadway” in 1995. “It’s really nice to get validation, and we worked really hard on that film. The entire movie was improvised, and everyone came up with their own characters.” “The whole movie is in Chinese except my scenes. It’s a sweeping epic. The Chinese girls in scenes with me had to learn to speak English phonetically.” Not only does she do a lot of work in independent films, but she attends professional poker tournaments throughout the world. She won the World Series of Poker bracelet in 2005 and regularly appears in televised poker events. “My boyfriend \ is a professional poker player, and I have an alternative career. I won the gold bracelet, and it’s like winning an Olympic gold medal. Poker is one of those amazing games like chess where you never master it. It’s been hard having two careers. … I have literally in my hallway eight suitcases that have not been unpacked. I’m always on the go. I’ve always been a workaholic.” For an extended version of the Jennifer Tilly story and more celebrity news, go to Greg Hernandez’s daily Hollywood Joe blog at blogs.dailynews.com/hollywoodjoe. 160Want local news?Sign up for the Localist and stay informed Something went wrong. Please try again.subscribeCongratulations! You’re all set!last_img

Unique experimental vaccine against Zika virus proves powerful in mice

first_imgAug 6 2018A uniquely designed experimental vaccine against Zika virus has proven powerful in mice, new research has found.A team led by researchers at The Ohio State University has developed and tested a vaccine that employs an uncommon two-pronged approach to fighting the virus, which is spread by mosquitos and is most serious for pregnant women and their fetuses.The single-dose vaccine, carrying the genes for two or three Zika proteins, proved effective in triggering an immune response that prevented later infection by Zika virus, according to the study, which appears in the journal Nature Communications.”In this study, the vaccine was potent, safe and highly effective, at least in the short term. There’s a long way to go, but we think this is a promising candidate for a human vaccine,” said Jianrong Li, an Ohio State professor of veterinary biosciences who led the study and developed the vaccine platform.Babies born to Zika-infected mothers are sometimes born with a birth defect called microcephaly. Other complications include miscarriage, stillbirth and other birth defects. Research also suggests that a small percentage of people infected with the virus can contract Guillain-Barre syndrome, which affects the nervous system.There’s no vaccine available currently – though some are in clinical trials – and the only protection against Zika are preventative measures such as insect repellant, staying indoors and wearing long sleeves and pants.Shan-Lu Liu, a study co-author and director of Ohio State’s Viruses and Emerging Pathogens Program, said the experimental vaccine holds particular promise because it appears to afford an adequate immune response with one dose. In hard-to-reach and resource-poor areas, that becomes especially valuable, he said.When this study began, the Ohio State team wondered if a novel approach to vaccination might prove effective against the virus – one in which they targeted a protective immune response by expressing two or three Zika proteins.As a vehicle for the Zika proteins, they looked to vesicular stomatitis virus, or VSV, which is a foot-and-mouth disease in cattle. The weakened form of the virus is harmless in humans and mice. VSV has been used in other vaccines, including a successful Ebola vaccine which has been used in preventing outbreaks in humans in Africa.”It’s a good platform for human vaccines, because people don’t have any antibodies against it and that allows VSV to successfully transport the vaccine without being stopped by the immune system,” said study co-author Mark Peeples, a pediatrics professor at Ohio State and researcher at Nationwide Children’s Hospital in Columbus.Related StoriesHPV vaccine has led to a dramatic reduction in cervical cancer rates, but Africa is lagging behindNew shingles vaccine reduces outbreaks of painful rash among stem cell transplant patientsVirus killing protein could be the real antiviral hero finds studyIn general, vaccines work by delivering harmless amounts of the target virus proteins to the bloodstream, allowing the body to build up immune responses that will provide protection in the event of subsequent exposure to the virus. Li’s work has been focused on weakening VSV so that it doesn’t cause any problems and then inserting genes from other viruses to make powerful vaccines, said Peeples, who first encouraged Li to consider applying his vaccine platform to Zika.In the experimental vaccine, VSV acts as a vehicle to deliver the genes for two or three key proteins from the Zika virus, carrying them into the mouse and expressing them inside some of the cells in the mouse so that the immune system could respond and build up a defense against Zika.”The addition of NS1 protein is an innovative approach for a vaccine – it’s a protein that is made after the Zika virus infects a cell. It’s what this bug uses to replicate itself once it’s inside the host,” said Prosper Boyaka, a study co-author and Ohio State professor of veterinary biosciences.The study included experiments in mice with severely compromised immune systems – a necessary step to make sure that mice could get sick after infection with Zika virus. When the vaccinated mice were exposed to Zika virus, their weak immune systems fought it off swiftly and efficiently, convincing the research team that their design had worked.Without using the immunocompromised animals, the researchers would not have known how safe and effective the vaccine was, Peeples said.The early success with this vaccine has encouraged this team to use the same approach to fight other related viruses, including Dengue fever, the researchers said.The researchers also looked at the response to a vaccine with just the unique NS1 gene inserted into VSV and for the first time established that it offered partial protection all on its own, confirming its value in the vaccine, Boyaka said.”We are very excited to find that VSV-based Zika vaccine is highly promising in both immunocompetent and immunocompromised mice”, said Anzhong Li, who is the first author of the paper and a graduate student in Jianrong Li’s laboratory. Anzhong Li recently presented these findings at a scientific conference in Italy.”Really, the next big question is ‘Will this be protective in humans?’ ” Peeples said.Source: https://news.osu.edu/novel-vaccine-approach-proves-powerful-against-zika-virus/last_img read more