Based on 100,000 simulations of the 2019 MLB seasonSources: Baseball prospectus, Fangraphs, Clay Davenport, Caesar’s Palace Avg. Simulated SeasonChance to… Teams that won substantially more than 100 games have tended to regress even harder. The 2002 Mariners, for example, won “only” 93 games after the 2001 squad tied a major league record with 116 wins; the 1999 Yankees won 98 a year after the team took home 114. The inescapable truth is that few major league teams actually have 100 wins of “true talent” on their rosters, much less 108. Most of these huge winners were aided by some not-insignificant amount of luck along the way.And it’s hard to argue that the Red Sox weren’t one of the luckier teams in baseball last season. According to the Pythagorean expectation, a team with Boston’s runs scored and allowed should have won four games fewer than it actually did. Furthermore, a team with Boston’s particular statistical profile (its singles, doubles, walks, etc. — both for and against) should have had a Pythagorean record five games worse than it actually did. Add up those two categories, and the Red Sox benefited from an MLB-high 10 extra wins of luck, whether through prevailing in the relative toss-ups of close games or through stringing hits together (or stranding opposing runners) in an unusually favorable manner.On top of all that, there’s another way a team can have everything go right for it, and that’s at the player level: Did everyone outperform their expected levels of performance at once? Injuries can often play a role here — though the Red Sox were in the middle of the pack in terms of man-games lost to the injured list. More pertinently, Boston also saw a number of players post career-best seasons last year, from American League MVP Mookie Betts (10.6 wins above replacement)4Averaging together the versions of WAR from Baseball-Reference.com and FanGraphs. to blockbuster free-agent signing J.D. Martinez (6.1), plus young up-and-comers such as Andrew Benintendi (4.1) and even longtime puzzles such as Eduardo Rodriguez (2.7).Altogether, 12 of Boston’s 21 regulars (those who played at least 2 percent of the team’s available playing time)5As measured by plate appearances and (leverage-adjusted) innings pitched, scaled to maintain WAR’s implicit 58/42 split between position players and pitchers. exceeded their established level of WAR, with only Jackie Bradley Jr., Eduardo Nunez and the catching tandem of Sandy Leon and Christian Vazquez significantly undershooting their previous production levels during the 2018 regular season.6You could also argue that more should have been expected of Rafael Devers, who had 1.1 WAR in a partial season at age 20 in 2017 but produced only 0.5 WAR with more than double the playing time in 2018. But Devers was also only 21, playing his first season as an MLB regular.And this is to say nothing of the unexpected performances the team received in the postseason from the likes of Steve Pearce — a fizzled-out former prospect who arrived in Boston via a midseason trade and ultimately won World Series MVP — or Nathan Eovaldi, another castoff who had a 1.61 ERA in 22 1/3 postseason innings. (Or, in general, the amazingly fortuitous splits the team had in crucial playoff situations.)All of those different ingredients explain how a team that won 93 games in 2017 suddenly exploded for 108 and won the championship a year later. But again, the pull of baseball’s gravity is strong. Based on data since 1990, we’d expect a team that improved by 15 games between seasons to give back about 5.2 wins the next season. It’s just another data point to toss onto the heap of statistical indicators that foretell a decline for the Red Sox heading into 2019.The good news for Boston is that if your starting point is a 108-win team, you have a ton of room to regress and still be one of the best teams in baseball. Even if the Sox didn’t truly have 108 wins of talent on the roster last year, they still played like a 98-win team according to their underlying statistics, and almost all of that team will be back this season (with the notable exception of closer Craig Kimbrel). According to an early preseason version of our 2019 MLB projections,7Not including Tuesday’s news of Manny Machado signing with the San Diego Padres, although that move has minimal implications for the Red Sox. we rate Boston as the third-best team in baseball, with a 95-67 projected record and a 10 percent chance of repeating as champs, which is also tied for third-best in MLB.Trouble is, that might make the Red Sox only the second-best team in their own division. Our simulations consider the archrival New York Yankees just as likely as Boston to win the World Series and actually think that New York is ever-so-slightly better talent-wise. Although the Sox got the better of the Yankees last season, winning 13 of 23 games (including an August sweep and a four-game division series victory), for all intents and purposes, our projections have the two teams in an absolute dead heat as we look ahead to 2019: And the Red Sox could be running out of time to make the most of their current core. By 2021, Betts, Bradley, Chris Sale, Xander Bogaerts and Rick Porcello (plus potentially Martinez, who has an opt-out clause) will have all hit free agency. And team president Dave Dombrowski built 2018’s champion in part by bucking MLB’s prospect-hoarding trend and emptying out the farm system’s next generation in favor of short-term wins, so reinforcements aren’t exactly on the way.The result of Dombrowski’s moves was a championship, and one of baseball’s all-time great single season performances, so I’m pretty sure it was worth it. The question now is how steep the drop-off will be in 2019 — and beyond. In many ways, Boston caught lightning in a bottle last season, enjoying the kind of magical year that comes along only once every decade or so. But if history is any guide, the follow-up will have trouble coming close to matching the original. TeamElo RatingWinsLossesRun Diff.Make PlayoffsWin DivisionWin World Series Orioles142160102-1981<1<1 The Red Sox still have a Yankees problem on their handsHow our preliminary Elo ratings are forecasting the 2019 AL East race Yankees15669567+13774%41%10% Blue Jays14837587-521331 It’s hard to imagine things going more right for the Boston Red Sox than they did last season. Boston jumped out to a scorching 17-2 start, was 38 games over .500 by the All-Star break, posted the most regular-season wins (108) by an MLB team in 17 years, and then steamrolled through the playoffs with an 11-3 postseason record en route to a World Series title. Statistically, it was probably the most impressive performance any major team had in 2018.1Among teams for which we had have game-by-game Elo ratings and predictions — in men’s pro and college football and basketball and Major League Baseball.But now the calendar has flipped to 2019, and as spring training warms up for the Sox in Fort Myers, Florida, Boston must focus on defending its crown — and staving off the inevitable regression that comes in the wake of a season as charmed as the one the Red Sox just enjoyed.As a rule, clubs that win a crazy number of ballgames in one season tend to come back down to earth quickly in the next. Of the 32 teams that cracked the century mark in wins (per 162 games)2We’re including teams in strike-shortened seasons — like the 1994 Montreal Expos — whose wins would prorate out to at least 100. since 1990, 28 had an inferior record the next year,3One team — the 101-win 2003 Yankees — compiled the same number of wins the next season. and 24 failed to return to the 100-win club. (Thirteen failed to break even 95 wins.) On average, these 32 triple-digit winners declined by 9.6 wins the following season. Rays15278676+5042153 Red Sox15649567+136744110
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Marcel Desailly has backed the inexperienced France squad to cause a surprise in the upcoming World Cup in RussiaLes Bleus somewhat struggled in the qualifying stages of the World Cup and have been drawn against the likes of Australia, Peru and Denmark in Group C for this summer’s tournament.But Desailly, who himself won the 1998 World Cup with France, is convinced that they have the quality to do well in the tournament and believes that their opponents in Group C will be relatively easy compared to the rest of the competition.“They have quality but not the experience, so we hope that the group stage, which is apparently not that difficult, will allow them to build up the confidence that they need,” said the 49-year-old, according to Gulf News.“When you top up confidence plus talent you hope that yes, France will now surprise everyone.Opinion: Neymar will earn respect back from the PSG fans Tomás Pavel Ibarra Meda – September 14, 2019 After completing his incredible return to Parc des Princes, we predict that Neymar will earn the respect back from PSG supporters.The situation between Neymar…“They surprised us during the Euros when we were not sure they were capable of reaching the final, and they almost won, so maybe they can do the same with the World Cup.“We need a win, it’s been too long. It’s the 20th anniversary of us winning the World Cup, so it would be good if they could win it this year.”France previously finished as the runners-up in Euro 2016, but Desailly warned that a lot has changed since then and fears that team boss Didier Deschamps is yet to find a system to properly utilise the new players in the squad.“We’ve lost all confidence built up during the Euros, we’ve lost our left and right backs in defence (Patrice Evra and Bacary Sagna have retired from international football), and we have new players who have to adapt to each other. Didier Deschamps doesn’t really know about his tactical set-up or his philosophy, so there’s quite a lot of work to do.” said the former Chelsea defender.“The Euros are gone and now you are starting a new movement. You can say they are ready for the next Euros hoping maybe that they are going to surprise everybody at the World Cup — that is the position of France.”
Share Diana Nguyen / Marfa Public RadioSharon Wilson checking out an oil and gas facility near Balmorhea.Funky smelling fumes, dimmer skies, and increased health concerns have all been reported by residents in the Southwest corner of the Permian Basin as the oil and gas industry expands. Growth has been happening north of the Davis Mountains over the last two years. Concerns about greenhouse gases and toxic emissions have spurred some citizens — like Sharon Wilson — to try to keep oil companies accountable themselves, one rig at a time.During a recent drive along roads in Reeves County near Balmorhea, Wilson is hunting for oil and gas emissions.Specifically, hydrocarbons like methane, benzene, and other vapors escaping from oil and gas facilities. Today she’s checking out sites owned by the Houston-based Apache Corporation.As she gets out of her car, Wilson points out the odor.“Can you smell it? It’s definitely pretty stinky.”Wilson is a part of Earthworks, an environmental advocacy group that says oil and gas operations are threatening the health of people who live in the South Permian Basin and the environment. Other than her nose, she uses a special infrared camera to find chemicals the human eye can’t see.Diana Nguyen / Marfa Public RadioSharon Wilson using an FLIR camera to track oil and gas emissions.At a glance, a pipe at a natural gas site may not seem like much until Wilson points her camera at it. She says, “I’ll show you in the camera. All of this equipment along here, you’re going to see a lot of air pollution. It’s pretty alarming.”Wilson’s camera can reveal plumes of smoke pouring into the air, though the camera can’t tell the difference between say, steam or toxic chemicals. But, Wilson is pretty sure what she’s seeing is pollution.“If you’re seeing something and it’s coming from the equipment on an oil and gas site then the gases are most likely going to be hydrocarbons. No matter what the industry tries to tell us. It’s certainly not cotton candy.”There is a certain amount of emissions oil and gas sites are allowed to legally discharge. Apache Corporation maintains they stay within emission standards. But, in general, Wilson and Earthworks say operators in Texas aren’t being monitored enough.“Nobody’s measuring it. The state does not go out and measure it. The state is not out here doing air testing.”Diana Nguyen / Marfa Public RadioSharron Wilson on the side of a Reeves County road.Professor Gunnar Schade of Texas A&M University agrees. “I often get asked why are we not finding these [leaks], supposedly there are so many leaks out there,” he said. “Well, the dominant leaks occur where you’re not looking.”Schade has a doctorate in natural sciences and his research focuses on the transfer of gases to the atmosphere. He says regulators aren’t keeping up with the Texas oil industry when it comes to hydrocarbon leaks. The Texas Commision on Environmental Quality, or TCEQ, disagrees. It’s the department in charge of monitoring emissions discharged by completed wells and refineries. In a statement, TCEQ told Marfa Public Radio it does routine inspections of oil and gas sites and has air quality monitoring stations around the state. In the Permian Basin, the commission has four stations to assess the general air quality of the region, which spans thousands of miles.TCEQ also allows companies to do their own assessments. If a company performing a self-evaluation reports a violation it is immune from any penalties. To Schade, these safeguards aren’t doing the job. He says there’s evidence that too many greenhouse gases and toxins are escaping from facilities.Schade also thinks this is a situation that has a simple solution. “Fixing this problem is easy. You do what the prior administration had a suggested. Mainly you look for where the biggest leaks are and you fix those,” he said.For this to work, regulators, like TCEQ, would need to go to every site and do inspections, but Schade says, “Right now, that’s not being done.” According to him, if people want TCEQ to respond to oil and gas sites they’re worried about they need to make their voices heard.“There’s not going to be much response from the regulatory side unless people speak up and say this pad over here I think has a lot of emissions because I wake up with a bloody nose every morning or I smell it all the time.”In an email, a TCEQ official wrote if a leak is an “imminent threat to health or to the environment” they’ll respond within 24 hours or less.Mitch Borden / Marfa Public RadioBalmorhea’s water tower.Before late 2016 there wasn’t really any oil development around Balmorhea. It was known for its pristine natural springs and clear skies. Now, some individuals are claiming emissions are affecting their health and the region’s skies are getting murkier as oil development ramps up.Alfredo Gutierrez is a truck driver from Chicago who hauls freight all over the country. While driving through the Southern Permian Basin for the first time he says he spotted something.“When the sun was going down I saw like the smoke on the air and it was like a clear sky, but this was a different kind of smoke.”Gutierrez is describing the dense haze that sometimes hangs low in the sky around Balmorhea, which he wasn’t expecting to see.“You see this in like a city like Dallas [or] Houston, but not in here with nothing around,” he said. “This is probably like a really contaminated place.”There is no way to tell where the haze is coming from because there is little to no data on the air quality in the Southern Permian Basin and Big Bend. That’s about to change though. Later this month, Dr. Gunnar Schade will begin a year-long project, tracking emissions around Reeves County. This study should establish a baseline record of air quality for future research and help form a better picture of how the oil and gas industry is affecting the South Permian Basin.Diana Nguyen contributed to this report. This article was originally published on Marfa Public Radio.
Story Links GAME DAY INFORMATION #8 Louisville vs. Brown Location: Louisville, Ky. Venue: Jim Patterson Stadium (4,000) Twitter Updates: @LouisvilleBSB Game Notes: Louisville | Brown Florida State 556 LOUISVILLE TABBED AS PRESEASON ACC FAVORITEThe Louisville baseball team was voted as the 2019 ACC preseason favorite by the league’s 14 head coaches. The Cardinals were selected as the favorite in both the Atlantic Division and the conference.Louisville received seven first place votes in the Atlantic Division and tallied 90 points to narrowly edge out Florida State, which picked up six votes for the top spot and 86 points. Clemson was third with 71 points followed by NC State (53), Wake Forest (49), Notre Dame (24) and Boston College (19).North Carolina was a near unanimous selection to win the Coastal Division, as 13 coaches voted the Tar Heels in the top spot. Virginia received the other first place tally and is tied with Duke for the second position with 64 points. Miami (61), Georgia Tech (59), Pitt (24) and Virginia Tech (23) round out the rest of the division.LOUISVILLE IN NATIONAL POLLS EVERY WEEK SINCE START OF 2012Louisville, which surpassed its previous high national ranking of No. 2 (in 2016) with the No. 1 ranking on March 13 and March 20 during the 2017 season, has enjoyed a historic run by remaining ranked in at least one major national poll every week since the release of the 2012 preseason rankings — the longest such span in school history.Ranked in the top 25 in all six major preseason polls for 2019, the Cardinals have earned a preseason national ranking in 11 straight seasons (2008-2018) overall. Louisville entered the 2019 season ranked fourth in the D1Baseball rankings, eighth in the Perfect Game and USA Today polls, ninth in the Collegiate Baseball Newspaper and NCBWA rankings and 11th by Baseball America.BENNETT AND WYATT RECEIVE 2019 PRESEASON ALL-AMERICA RECOGNITIONA pair of Louisville players were named preseason All-Americans in 2019 by various organizations. Junior first baseman Logan Wyatt garnered preseason All-America honors from Baseball America, Collegiate Baseball Newspaper, D1Baseball, NCBWA and Perfect Game. Additionally, junior lefthanded pitcher Nick Bennett was a preseason All-America selection by the NCBWA and Perfect Game.A Louisville native, Wyatt earned Third Team All-America recognition from Collegiate Baseball newspaper and was an All-ACC First Team honoree as a sophomore last season after hitting .339 with six home runs, 69 RBIs, 22 doubles, 63 walks, 51 runs scored, .559 slugging percentage and .490 on-base percentage. He closed 2018 ranked third in the NCAA in walks, 15th in on-base percentage, 17th in RBIs and 18th in doubles. Wyatt was also named to the 2018 NCAA All-Lubbock Regional Team after finishing 6-for-16 with two home runs and 10 RBIs in four NCAA Regional games.Bennett, a junior from Cincinnati, Ohio, closed his sophomore season with an 8-2 record, 2.84 ERA and 72 strikeouts in 73.0 innings pitched, including 11 starts. He was an All-ACC Second Team honoree and was an All-ACC Academic Team selection in 2018. During his first collegiate season in 2017, Bennett earned Freshman All-America honors and was an All-ACC Third Team selection while accumulating a 5-1 record, 3.18 ERA and 61 strikeouts in 65.0 innings pitched and 15 total appearances, including 13 starts.WYATT NAMED TO USA BASEBALL GOLDEN SPIKES AWARD WATCH LISTJunior first baseman Logan Wyatt was named to the preseason watch list for the 2019 USA Baseball Golden Spikes Award. The list features 55 of the nation’s top amateur players across high school and college baseball.Wyatt is the 11th Cardinal to appear on the preseason watch list since 2009, including Brendan McKay who won the Golden Spikes Award in 2017.An All-American in 2018, Wyatt has garnered preseason All-America honors in 2019 from Baseball America, Collegiate Baseball Newspaper, D1Baseball, NCBWA and Perfect Game. The Louisville native was an All-ACC First Team honoree as a sophomore last season after hitting .339 with six home runs, 69 RBIs, 22 doubles, 63 walks, 51 runs scored, .559 slugging percentage and .490 on-base percentage. Wyatt was also named to the 2018 NCAA All-Lubbock Regional Team after finishing 6-for-16 with two home runs and 10 RBIs in four NCAA Regional games.LOUISVILLE LEADS COUNTRY IN WINS SINCE 2007Dan McDonnell took the reins of the Louisville baseball program in 2007. Louisville entered 2019 with the most wins of any Division I program from 2007-18 with 554. LOUISVILLE, Ky. — After opening the 2019 home season with a win over Eastern Kentucky, the eighth-ranked Louisville baseball team will play a three-game series against Brown at Jim Patterson Stadium starting with a doubleheader on Friday at 2 p.m., ET. The series is scheduled to wrap up on Saturday at 2:00 p.m., ET. All three games can be seen on ACC Network Extra and radio coverage will be available on 1450 WXVW on Friday and will transition over to 93.9 The Ville beginning at 6:00 p.m., ET. Saturday’s game can be heard on 93.9 The Ville. Live scoring is available at GoCards.com.ABOUT THE LOUISVILLE CARDINALSThe Cardinals bounced back from a series loss against Connecticut with a 5-1 victory over Eastern Kentucky on Tuesday. Junior Luke Smith made his first start on the mound as a Cardinal and picked up the win after six strong innings. Smith allowed just one unearned run on two hits while striking out six.Junior shortstop Tyler Fitzgerald had two of Louisville’s five hits on the day. Fitzgerald had a hand in four of the five runs, driving in a pair with a double in the first inning and scoring twice.Louisville is in the midst of a 14-game homestand after three games in Florida to start the season. The Cardinals will not hit the road again until a three-game set at Duke beginning on March 15.The Cardinals began head coach Dan McDonnell’s 13th season ranked as high as fourth in the national polls. UofL is coming off a 45-19 record in 2018, its seventh straight 40-win season and the 11th in 12 seasons under McDonnell. The Cardinals advanced to the championship round of an NCAA Regional for the seventh straight season.ABOUT BROWNFriday’s series opener will be the season opener for Brown. The Bears were 11-26 in 2018 and finished last in the Ivy League. Brown was picked to finish at the bottom of the conference again in 2019.SERIES HISTORYLouisville and Brown have only met two times previously, with Brown sweeping a doubleheader against the Cardinals on April 8, 1972 in Louisville. The Cardinals are 3-2 all-time against current members of the Ivy League, with the three wins coming in a weekend sweep of Princeton in March of 2016.TEAM NOTES AND TRENDS 5. Vanderbilt 540 Louisville has had at least one baserunner in 32 of 35 offensive innings this season. The Cardinals have left at least nine runners on base in all four games in 2019, and 42 total for the season. Louisville has scored first in all four games this season and in the first inning in three of four. In three of Louisville’s first four games, the starting pitcher has pitched five innings or more with one earned run or fewer allowed. Eleven different Cardinals have made their Louisville debuts in the first four games (Binelas, Davis, Leonard, Lohman, Masterman, Metzinger, Perkins, Poland, Schmeltz, Smith and Wright). It was the collegiate debut for 10 of the 11. Louisville has 24 games on its schedule against teams ranked inside the top 25 in at least one of the six major preseason polls (Clemson, Connecticut, Duke, Florida State, Georgia Tech, Mississippi, NC State, Vanderbilt and Wake Forest). Seven pitchers made weekend series starts in 2018 but the Cardinals used the same trio in the final seven weeks of the regular season — Adam Wolf, Nick Bennett and Bobby Miller. Five different Louisville pitchers earned saves last season, including three in the series sweep at Pittsburgh (Shay Smiddy, Michael McAvene and Adam Elliott) on May 11-13. The Cardinals were 39-4 in 2018 when entering the ninth inning with a lead. From 2012-17, Louisville accumulated a six-year record of 266-3 when entering the ninth with a lead, including a 50-0 mark in 2017. On the mound, Louisville was 5th in the nation in 2018 in hits allowed per 9 IP (7.40), 19th in strikeouts per 9 IP (9.5) and 27th in ERA (3.53). UofL led the ACC in ERA and hits allowed per 9 IP. Louisville was ranked 5th in the nation and No. 1 in the ACC in stolen bases in 2018 with 125 in 149 attempts after ranking 17th in 2017 (98-of-123). The Cardinals were 12th in the NCAA in 2016 with 101 stolen bases, fourth nationally with 127 stolen bases in 2015, second in the nation in 2014 with 133 and second in 2013 with 150. Offensively in 2018, the Cardinals were 8th in the NCAA in sacrifice flies (36) 10th in walks (333), 11th in on-base percentage (.400) and 12th in doubles (131). Louisville led the ACC in doubles. UofL has won 31 of its 40 ACC series since joining the league and is 33-6 in its series finales during that span, including an 11-4 record in rubber games. The Cardinals have won 16 of their 20 ACC series at home since debuting in the conference. While at Louisville, coach Dan McDonnell has guided the Cardinals to four College World Series berths, seven NCAA Super Regional appearances, 11 NCAA Regional bids, eight regular season conference championships and two conference tournament titles with 37 All-Americans. 1. Louisville 556 4. North Carolina 553 Friday, Feb. 22 | 6:00 p.m. ET | Live Stats TV: ACC Network Extra | Radio: 93.9 The Ville LOU: Jr. LHP Nick Bennett (1-0, 0.00 ERA) BU: Jr. RHP Will Tomlinson Saturday, Feb. 23 | 2:00 p.m. ET | Live Stats TV: ACC Network Extra | Radio: 93.9 The Ville LOU: Sr. RHP Bryan Hoeing (0-1, 11.25 ERA) BU: Jr. RHP Garett Delano 3. LSU 555 LOUISVILLE 2018 RECRUITING CLASS AMONG BEST IN COUNTRYThe University of Louisville baseball program received its highest recruiting ranking in program history after D1Baseball tabbed the 2018 class at No. 3 in the nation. Louisville’s 2018 class was also ranked fourth nationally by Baseball America and Collegiate Baseball Newspaper.The 2018 class ranking marked the ninth time in the last 11 years Louisville has earned a top 25 national recruiting ranking under the guidance of head coach Dan McDonnell. The Cardinals had the top class in the ACC according to D1Baseball and was among five ACC programs in the top 25 classes – No. 6 Florida State, No. 8 Miami, No. 12 Clemson and No. 17 Virginia.FEELING AT HOME INSIDE JIM PATTERSON STADIUMSince opening the gates at Jim Patterson Stadium in 2005, the Cardinals have won more than 77 percent of their games in the ballpark posting a 372-107 record (.777 winning percentage), including an impressive 33-4 mark during the 2017 season at the corner of Third and Central. Louisville set a school record for home wins with 36 in 2016 and the Cardinals have registered 30 or more wins at home in four of the last six seasons.BENNETT, FITZGERALD, PINKHAM, WYATT NAMED TEAM CAPTAINSLefthanded pitcher Nick Bennett, infielder Tyler Fitzgerald, catcher Zeke Pinkham and first baseman Logan Wyatt have been selected by University of Louisville players and coaches as team captains for the Cardinals baseball team in 2019.Bennett, a junior from Cincinnati, Ohio, closed his sophomore season with an 8-2 record, 2.84 ERA and 72 strikeouts in 73.0 innings pitched, including 11 starts. He was an All-ACC Second Team honoree and was an All-ACC Academic Team selection in 2018. During his first collegiate season in 2017, Bennett earned Freshman All-America honors and was an All-ACC Third Team selection while accumulating a 5-1 record, 3.18 ERA and 61 strikeouts in 65.0 innings pitched and 15 total appearances, including 13 starts.A junior from Rochester, Illinois, Fitzgerald had a .264 batting average with three home runs, 17 doubles, 24 RBIs, 57 runs scored and 23 stolen bases in 24 attempts while playing in all 64 games in 2018, including 63 starts. Fitzgerald was named to the 2018 All-ACC Academic Team.Hailing from Elizabethtown, Kentucky, Pinkham has made 58 appearances with 26 starts behind the plate during his three seasons with the Cardinals. After missing the 41 games of 2018 recovering from off-season injury, Pinkham closed his junior season with 17 appearances and 11 starts.A Louisville native, Wyatt earned Third Team All-America recognition from Collegiate Baseball newspaper and was an All-ACC First Team honoree as a sophomore after hitting .339 with six home runs, 69 RBIs, 22 doubles, 63 walks, 51 runs scored, .559 slugging percentage and .490 on-base percentage. He closed the 2018 season ranked third in the NCAA in walks, 15th in on-base percentage, 17th in RBIs and 18th in doubles. Wyatt was also named to the 2018 NCAA All-Lubbock Regional Team after finishing 6-for-16 with two home runs and 10 RBIs in four NCAA Regional games.ALL LOUISVILLE BASEBALL GAMES SLATED FOR RADIO COVERAGEEach of Louisville’s 56 regular season games as well as all postseason games can be heard on radio locally in Louisville and online via TuneIn.com.Sean Moth will once again be on the call of Louisville baseball games this spring, while 93.9 The Ville will serve as the flagship station for the fifth consecutive season. Selected games during the regular season will be broadcast on 1450 WXVW. Friday, Feb. 22 | 2:00 p.m. ET | Live Stats TV: ACC Network Extra | Radio: 1450 WXVW LOU: So. LHP Reid Detmers (0-0, 1.80 ERA) BU: So. RHP Collin Garner Most Wins Since 2007 ESPN Louisville, the group behind local stations ESPN 680 and 105.7 FM, launched 93.9 The Ville, powered by ESPN, on Jan. 29, 2015. The station provides coverage of the Cardinals through an official partnership with Louisville Sports Properties, which represents UofL athletics.LOUISVILLE TO PLAY 52 GAMES ON ESPN NETWORKSLouisville’s 2019 television schedule features 52 of 56 regular season games set for ESPN platforms. The 52 regular season games scheduled for television coverage matches the 2018 season for most in program history.The television schedule is headlined by a pair of games slated for ESPNU. The Cardinals will host Vanderbilt on May 7 in the annual Battle of the Barrel and will later appear on ESPNU May 14 at Indiana.Forty-eight of the 52 games will be televised exclusively on ACC Network Extra, available on WatchESPN and the ESPN app. The Cardinals will also appear on SEC Network+ on the road at Kentucky on April 16 and on ESPN+ at Eastern Kentucky March 19. Print Friendly Version
Ball-and-stick model of lincomycin. Credit: Jynto/Wikipedia Journal information: Nature Scientists study how marine bacteria release cloud-making compound Citation: Researchers unravel the elusive source of sulfur in an antibiotic (2015, January 15) retrieved 18 August 2019 from https://phys.org/news/2015-01-unravel-elusive-source-sulfur-antibiotic.html Explore further More information: Metabolic coupling of two small-molecule thiols programs the biosynthesis of lincomycin A, Nature (2015) DOI: 10.1038/nature14137AbstractLow-molecular-mass thiols in organisms are well known for their redox-relevant role in protection against various endogenous and exogenous stresses1, 2, 3. In eukaryotes and Gram-negative bacteria, the primary thiol is glutathione (GSH), a cysteinyl-containing tripeptide. In contrast, mycothiol (MSH), a cysteinyl pseudo-disaccharide, is dominant in Gram-positive actinobacteria, including antibiotic-producing actinomycetes and pathogenic mycobacteria. MSH is equivalent to GSH, either as a cofactor or as a substrate, in numerous biochemical processes4, most of which have not been characterized, largely due to the dearth of information concerning MSH-dependent proteins. Actinomycetes are able to produce another thiol, ergothioneine (EGT), a histidine betaine derivative that is widely assimilated by plants and animals for variable physiological activities5. The involvement of EGT in enzymatic reactions, however, lacks any precedent. Here we report that the unprecedented coupling of two bacterial thiols, MSH and EGT, has a constructive role in the biosynthesis of lincomycin A, a sulfur-containing lincosamide (C8 sugar) antibiotic that has been widely used for half a century to treat Gram-positive bacterial infections6, 7, 8, 9. EGT acts as a carrier to template the molecular assembly, and MSH is the sulfur donor for lincomycin maturation after thiol exchange. These thiols function through two unusual S-glycosylations that program lincosamide transfer, activation and modification, providing the first paradigm for EGT-associated biochemical processes and for the poorly understood MSH-dependent biotransformations, a newly described model that is potentially common in the incorporation of sulfur, an element essential for life and ubiquitous in living systems. As Melancon notes, there are a host of molecules vital for biological processes that have sulfur as a component—their metabolic origins can be predicted as a matter of course. Sulfur atoms on the other hand have been much more difficult to predict. Overcoming such obstacles for some molecules could have benefits such as helping to develop new medicines. In this new effort the researchers set their sights on lincomycin A, an antibacterial agent that has been used to treat Gram-positive bacterial infections for many years.To find the sulfur source, the researchers used modern whole genome sequencing techniques to work backwards through likely pathways looking to isolate intermediaries that tended to build up as genes were disrupted. Doing so led to the discovery that disruption of lmbE led to intermediates that looked a lot like lincomycin—that led them to study lambV, a gene that also shows up in lincomycin, which led to the discovery of another intermediary. The team also tested other enzymes and found a way to prove that there were at least three of them that incorporated sulfur into parts of the antibiotic, which was the original goal, of course. More specifically, they found that two bacterial thiols played a constructive role in the biosynthesis of lincomycin A. The team then went further, isolating the materials that were produced due to the genes involved, along with the functions of enzymes that were part of the process.Work done by the team should help provide a pathway for other researchers attempting to find the source of sulfur atoms in other molecules, perhaps leading to new types of materials for use in a variety of medical purposes, from antibiotics to cancer fighting agents. © 2015 Phys.org (Phys.org)—A team of researchers working at the Chinese Academy of Sciences in Shanghai has for the first time found the source of sulfur atoms in lincomycin A, a lincosamide widely used as an antibiotic agent. In their paper published in the journal Nature, the team describes their research efforts and results. Charles Melancon with the University of New Mexico outlines and comments on the work done by the team in the same journal issue. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
Winter festivities and celebrations are gaining pace in the national Capital, where the stage is set for families to dive into the festive celebrations and to enjoy to their heart’s content.In a bid to boost tourism in the city, Delhi Tourism is organising ‘Winter Carnival’ from December 18-27 at Dilli Haat, INA and ‘X-Mas Carnival’ from December 25-27 at Dilli Haat, Janak Puri. To mark the beginning of the festive season, guests and visitors can look forward to a unique Christmas bazaar at both Dilli Haats, which is the main attraction and in order to build up the excitement, Santa Claus would be moving around the venue distributing candies to charm the little ones. To create a unique atmosphere, Church of Delhi would conduct singing of Christmas carols and cultural programmes every evening in order to light up the mood of the visitors. Dilli Haat Janakpuri will organise various other events like camel rides, joy rides, food delicacies of other states, cakes and chocolate stalls, adventure parks and handloom and handicraft stalls.