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first_imgThe selectors have opted to pick a completely new-look The selectors have opted to pick a completely new-look team for the tour of Zimbabwe with Vidharbha left-handed opener Faiz Fazal, off-spinner Jayant Yadav, Punjab middle-order batsman Mandeep Singh and IPL star Yuzvendra Chahal being the uncapped players in the side. Mahendra Singh Dhoni will captain the squad as he will be largely out of action for the rest of the year owing to a lack of limited-overs assignments for India. The team for West Indies expectedly has five specialist pace bowlers — Ishant Sharma, Bhuneshwar Kumar, Shami, Thakur and Umesh Yadav — while Binny is also capable of chipping in. The squad has three spinners in Ravichandran Ashwin, Amit Mishra and Ravindra Jadeja, while Wriddhimaan Saha has been picked as the frontline wicketkeeper. Batsman K L Rahul can also keep wickets if required. Murali Vijay and Shikhar Dhawan are the two openers with the middle-order comprising Rahul, Kohli, Pujara, Rahane and Rohit Sharma. The Squads: Squad for West Indies: Virat Kohli (c), Ajinkya Rahane (v-c), Murali Vijay, Shikhar Dhawan, K L Rahul, Cheteshwar Pujara, Rohit Sharma, Wriddhimaan Saha, R Ashwin, Amit Mishra, Ravindra Jadeja, Ishant Sharma, Mohammed Shami, Bhuvneshwar Kumar, Shardul Thakur, Stuart Binny. Squad for Zimbabe: M S Dhoni (c), K L Rahul, Maneesh Pandey, Karun Nair, Ambati Rayudu, Rishi Dhawan, Axar Patel, Jayant Yadav, Dhawal Kulkarni, Jaspreet Bumrah, Barinder Sran, Mandeep Singh, Jaidev Unadkat, Yuzvendra Chahal. PTI SSR NRB PM MRM PMlast_img read more

Californias stem cell research fund dries up

first_img Sign up for our daily newsletter Get more great content like this delivered right to you! Country One legacy of California’s $3 billion stem cell research agency is the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at the University of Southern California in Los Angeles.  By Jocelyn KaiserJul. 9, 2019 , 3:35 PM California’s stem cell research fund dries up Click to view the privacy policy. 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That reality set in last month, when the California Institute for Regenerative Medicine (CIRM) in Oakland announced it is no longer taking grant applications.Ongoing payments for approved projects continue, but scientists are already tightening their belts for a funding gap. They are also contemplating the end of a boom in stem cell research in the state. California’s voters may be asked to renew CIRM with another bond initiative next year, “but there’s no guarantee,” says Arnold Kriegstein, who heads a stem cell center at the University of California (UC), San Francisco, and has received CIRM funding in the past.Longtime CIRM grantee Jeanne Loring, who retired in June from the Scripps Research Institute in San Diego, California, and runs a biotech startup to advance one of her projects, says the agency has made the state the “center of the stem cell universe. It would be tragic to unravel [that infrastructure] now. But the funding in 2004 was so dependent on the politics and interest at the time, and I don’t know if those circumstances can be replicated.” ZUMA Press, Inc./Alamy Stock Photo That year 59% of California voters approved CIRM, which had been placed on the ballot as a response to restrictions imposed by then-President George W. Bush’s administration on the use of federal funding for studies of stem cells derived from human embryos. At the time, the National Institutes of Health (NIH) could only fund work on a small number of preexisting human embryonic cell lines. (Former President Barack Obama’s administration later lifted those restrictions.)CIRM initially expected to focus on human embryonic stem cells, but later expanded its remit to more specialized adult stem cells such as those that form blood or the increasingly popular induced pluripotent stem (iPS) cells, created by reprogramming adult cells to an embryolike state. CIRM’s money led to the creation of major stem cell centers in California and lured several biotech companies to set up shop in the state. Although CIRM supported infrastructure, basic research, and training early on, in the past 3 years it has poured most of its remaining $759 million into clinical trials—a total of 55 of which are ongoing or completed to date—as the agency faced pressure to produce the medical treatments its supporters were initially promised.In a memo to its board released on 20 June, CIRM said it had received applications totaling $88 million in its latest funding call but had only $33 million left to distribute. The agency announced the next day that it was taking no new grant applications as of 28 June, aside from a sickle cell disease program jointly funded with NIH. “There is no money available for new projects,” CIRM communications director Kevin McCormack wrote in a 1 July blog post.Some researchers who explore the basic science of stem cells had already been looking for other funding sources as CIRM began to emphasize clinical work and their support wound down. But others, especially those planning clinical trials, will be hit hard. “It’s going to be a huge impact on my lab and many others if they end,” says April Pyle of UC Los Angeles (UCLA), whose 11-person group works on using muscle stem cells to treat muscular dystrophy. Her last CIRM grant ends in March 2020 and although she also has some NIH funding, it does not support the animal testing and other studies needed to move her work toward a clinical trial.Future clinical work will face “at best significant delays, and many projects to identify new therapies will stop” if the agency doesn’t continue, says gene therapy researcher Donald Kohn, who heads several such trials at UCLA.CIRM’s efforts to raise $200 million in bridge funding from private sources have been unsuccessful to date. Now, CIRM boosters are looking to a $5.5 billion bond initiative that real estate developer Robert Klein, who led the original push to create the agency, hopes to add to the November 2020 ballot.If approved, “We would hope there would be very little gap” in funding, McCormack says. But if the voters reject the initiative, he expects CIRM’s staff to dwindle and the agency to fold by about 2023.last_img read more